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Article Dans Une Revue Green Chemistry Année : 2020

The salt-free nickel-catalysed alpha-allylation reaction of ketones with allyl alcohol and diallylether

Résumé

The nickel-catalysed α-allylation of ketones with allyl alcohol and diallylether has been performed under neutral conditions. As no base is involved, the products are synthesized without salts as side products. The dppf/Ni(cod)2 catalytic system in MeOH at 80 °C has been shown as the most effective reaction system to afford tetrasubstituted derivatives from various cyclic and acyclic ketones with one or two mobile protons. This process combined with a metathesis step yields spirocyclic compounds according to a salt free synthetic sequence.

Domaines

Catalyse
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Dates et versions

hal-04323253 , version 1 (05-12-2023)

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Citer

Bouchaib Mouhsine, Abdallah Karim, Clement Dumont, Mathieu Sauthier. The salt-free nickel-catalysed alpha-allylation reaction of ketones with allyl alcohol and diallylether. Green Chemistry, 2020, Green Chemistry, 22, pp.950-955. ⟨10.1039/c9gc03619a⟩. ⟨hal-04323253⟩
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