Prevention of cisplatin-induced acute kidney injury: a systematic review and meta-analysis - Université de Lille Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Drugs Année : 2019

Prevention of cisplatin-induced acute kidney injury: a systematic review and meta-analysis

Résumé

OBJECTIVE: Cisplatin-induced acute kidney injury (CIA) is a serious adverse event that affects 20-40% of exposed patients, despite any implemented precaution to avoid it. The aim of this work was therefore to identify a relevant nephroprotective method for CIA. METHODS: We searched Pubmed, Embase, and Web of Science from 1 January 1978 to 1 June 2018, without language restriction. All studies (observational and interventional) assessing a CIA prevention method for adults receiving at least one course of cisplatin were eligible. The primary outcome was acute nephrotoxicity, as defined by the AKI-KDIGO classification (2012). The odds ratio and corresponding 95% confidence interval were used to assess the associations. We used narrative synthesis in case of heterogeneity regarding intervention, population, or outcome. When possible, a random-effects model was used to pool studies. The heterogeneity between studies was quantified (I2 RESULTS: Within 4520 eligible studies, 51 articles fulfilling the selection criteria were included in the review, assessing 21 different prevention methods. A meta-analysis could only be performed on the 15 observational studies concerning magnesium supplementation (1841 patients), and showed a significant nephroprotective effect for all combined grades of CIA (OR 0.24, [0.19-0.32], I222 CONCLUSIONS: While no method of prevention had so far demonstrated its indisputable efficacy, our results highlight the potential protective effect of magnesium supplementation on cisplatin-induced acute nephrotoxicity. BACKGROUND: This study is registered in PROSPERO, CRD42018090612.
Fichier non déposé

Dates et versions

hal-04346782 , version 1 (15-12-2023)

Identifiants

Citer

Aghiles Hamroun, Remi Lenain, Jean Joel Bigna, Elodie Speyer, Linh Bui, et al.. Prevention of cisplatin-induced acute kidney injury: a systematic review and meta-analysis. Drugs, 2019, Drugs, 79, pp.1567-1582. ⟨10.1007/s40265-019-01182-1⟩. ⟨hal-04346782⟩
14 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More