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Article Dans Une Revue ChemMedChem Année : 2021

Highly Active, Entirely Biobased Antimicrobial Pickering Emulsions

Résumé

We present the development of surfactant-free, silica-free and fully biobased oil-in-water antimicrobial Pickering emulsions, based on the self-assembly of β-cyclodextrin and phytoantimicrobial oils (terpinen-4-ol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bio-based drug to treat fungal infection, but is less effective than petroleum-based drugs as azole derivatives. To maximize its antifungal potential, we have incorporated UA in fully biobased Pickering emulsions. These emulsions are effective against fungi, Gram-positive and Gram-negative bacteria. The carvacrol emulsion charged with UA is +390 % and +165 % more potent against methicillin-resistant S. aureus (MRSA), compared to UA and azole-based commercial formulations. Moreover, this emulsion is up to +480 % more efficient that UA ointment against C. albicans. Finally, remarkable eradication of E. coli and MRSA biofilms was obtained with this environmental-friendly emulsion.

Dates et versions

hal-04347236 , version 1 (15-12-2023)

Identifiants

Citer

Loïc Leclercq, Jérémie Tessier, Véronique Nardello-Rataj, Andreea‐ruxandra Schmitzer. Highly Active, Entirely Biobased Antimicrobial Pickering Emulsions. ChemMedChem, 2021, ChemMedChem, 16 (14), pp.2223-2230. ⟨10.1002/cmdc.202100030⟩. ⟨hal-04347236⟩
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