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Article Dans Une Revue Neurophysiologie Clinique = Clinical Neurophysiology Année : 2023

Glaucoma-associated abnormalities in cortical activity during a visuocognitive task

Résumé

Objective: To investigate neurophysiological dynamics during a visuocognitive task in glaucoma patients vs. healthy controls. Methods: Fifteen patients with early-stage primary open-angle glaucoma (POAG) and fifteen age-matched healthy participants underwent a “go/no-go” task, monitored with electroencephalography (EEG). Participants had to semantically categorize visual objects in central vision, with animal or furniture as targets according to the experimental block. Results: Early visual processing was delayed by 50 milliseconds (ms) in patients with POAG compared to controls. The patients displayed a smaller difference between animal and furniture categorization during higher-level cognitive processing (at 400-600 ms). Regarding behavioral data, the groups differed in accuracy performance and decision criterion. As opposed to the control group, patients did not display facilitation and a higher accuracy rate for animal stimuli. However, patients maintained a consistent decision criterion throughout the experiment, whereas controls displayed a shift towards worse decision criteria in furniture trials, with higher error rate. Conclusions: The comparative analysis of behavioral and neurophysiological data revealed in POAG patients a delay in early visual processing, and potential high-level cognitive compensation during late, task-dependent activations. Significance: To our knowledge, our findings provide the first evidence of modification in cognitive brain dynamics associated with POAG.
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Dates et versions

hal-04354013 , version 1 (19-12-2023)

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Clementine Garric, Yannick Wamain, Jean-François Rouland, Quentin Lenoble. Glaucoma-associated abnormalities in cortical activity during a visuocognitive task. Neurophysiologie Clinique = Clinical Neurophysiology, 2023, Neurophysiologie Clinique = Clinical Neurophysiology, 156, p. 47-56. ⟨10.1016/j.clinph.2023.09.012⟩. ⟨hal-04354013⟩
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