A versatile approach for the elaboration of switchable titanium platforms through the Diels–Alder/retro Diels–Alder (DA/rDA) reactions is reported. For this purpose, catechol based biomimetic anchors integrating either a furan or a maleimide moiety were synthesized and grafted onto titanium surfaces. The DA cycloaddition reaction was then employed to chemically modify TiO2 surfaces and to tailor their wettability. The thermal reversibility of the Diels–Alder reaction was next exploited to switch the wettability of TiO2 surfaces. As a proof of concept, several probes including a ferrocene derivative, a hydrophobic (fluorinated) and a hydrophilic (poly(ethylene oxide)) oligomers were immobilized onto TiO2 surfaces and interchanged afterward. The course of chemical transformations of TiO2 surfaces as well as the faculty of their wettability to be switched (on demand) were investigated by electrochemical, contact angle, and XPS measurements.