Clinical Implications of Vertebral Endplate Disruptions After Lumbar Discectomy: 3-Year Results from a Randomized Trial of a Bone-Anchored Annular Closure Device
Résumé
Objective: Vertebral endplate disruptions (VEPD) are common findings on imaging after
lumbar surgery. The objective of this study was to explore the clinical implications of VEPD
development following lumbar discectomy with or without implant with a bone-anchored
annular closure device (ACD).
Methods: This was a multicenter randomized controlled trial of patients with large postsurgical annular defects after limited lumbar discectomy who were randomized to additionally receive an ACD or no additional treatment. VEPD were identified on computed
tomography and confirmed by an imaging core laboratory. Clinical outcomes included
recurrent herniation, reoperation, Oswestry Disability Index, leg pain, and back pain.
Patient follow-up in this study was 3 years.
Results: In the ACD group (n=272), the risk of reoperation was lower in patients with vs
without VEPD (8% vs 24%, p<0.01), but no other clinical outcomes differed when stratified
by VEPD prevalence or size. In the Control group (n=278), the risk of symptomatic
reherniation was higher in patients with VEPD (41% vs 23%, p<0.01) and patients with
the largest VEPD had the highest reoperation rates. Patient-reported outcomes were not
associated with VEPD prevalence or size in the Control group.
Conclusion: VEPD had no significant influence on patient-reported outcomes at 3 years
after lumbar discectomy. VEPD increased the risk of recurrence in patients treated with
lumbar discectomy only, but had no negative influence in patients treated with the ACD.
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