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Article Dans Une Revue European Journal of Nutrition Année : 2019

Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study.

Aline Arouca
  • Fonction : Auteur
A Moreno Luis
  • Fonction : Auteur
M Gonzalez-Gil Esther
  • Fonction : Auteur
Ascension Marcos
  • Fonction : Auteur
Kurt Widhalm
  • Fonction : Auteur
Denes Molnar
  • Fonction : Auteur
Yannis Manios
  • Fonction : Auteur
Anthony Kafatos
  • Fonction : Auteur
Mathilde Kersting
  • Fonction : Auteur
Michael Sjostrom
  • Fonction : Auteur
Jose Amaro-Gahete Francisco
  • Fonction : Auteur
Marika Ferrari
  • Fonction : Auteur
Marcela Gonzalez-Gross
  • Fonction : Auteur
Stefaan de Henauw
  • Fonction : Auteur
Nathalie Michels
  • Fonction : Auteur

Résumé

AIM: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. METHODS: In 618 adolescents (13-17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFbeta-1, C-reactive protein, TNF-alpha, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. RESULTS: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFbeta-1, GGT, and ALT. CONCLUSION: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.

Dates et versions

hal-04415635 , version 1 (24-01-2024)

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Citer

Aline Arouca, A Moreno Luis, M Gonzalez-Gil Esther, Ascension Marcos, Kurt Widhalm, et al.. Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study.. European Journal of Nutrition, 2019, European Journal of Nutrition, 58, pp.1947-1960. ⟨10.1007/s00394-018-1749-3⟩. ⟨hal-04415635⟩

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