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Article Dans Une Revue Journal of Pediatric Gastroenterology and Nutrition Année : 2019

Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER).

Assaf Hoofien
  • Fonction : Auteur
Jorge A Dias
  • Fonction : Auteur
Monica Malamisura
  • Fonction : Auteur
Francesca Rea
  • Fonction : Auteur
Sonny Chong
  • Fonction : Auteur
Johanna Oudshoorn
  • Fonction : Auteur
Danielle Nijenhuis-Hendriks
  • Fonction : Auteur
Sebastian Otte
  • Fonction : Auteur
Alexandra Papadopoulou
  • Fonction : Auteur
Claudio Romano
  • Fonction : Auteur
Victor V Miravet
  • Fonction : Auteur
Rok Orel
  • Fonction : Auteur
Salvatore Oliva
  • Fonction : Auteur
Carolina G Junquera
  • Fonction : Auteur
Andrzej Zaleski
  • Fonction : Auteur
Vaidotas Urbonas
  • Fonction : Auteur
Roger Garcia-Puig
  • Fonction : Auteur
Maria J M Gomez
  • Fonction : Auteur
Gloria Dominguez-Ortega
  • Fonction : Auteur
Marcus Auth
  • Fonction : Auteur
Michal Kori
  • Fonction : Auteur
Amir Ben Tov
  • Fonction : Auteur
Nicolas Kalach
  • Fonction : Auteur
Saskia V Velde
  • Fonction : Auteur
Mark Furman
  • Fonction : Auteur
Erasmo Miele
  • Fonction : Auteur
Luba Marderfeld
  • Fonction : Auteur
Eleftheria Roma
  • Fonction : Auteur
Noam Zevit
  • Fonction : Auteur

Résumé

OBJECTIVE: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists diagnosing and treating EoE and to identify the triggering allergens in European children. METHODS: Retrospective anonymized data were collected from 26 European pediatric gastroenterology centers in 13 countries. Inclusion criteria were: Patients diagnosis with EoE, completed investigations prescribed by the treating physician, and were on stable medical or dietary interventions. RESULTS: In total, 410 patients diagnosed between December 1999 and June 2016 were analyzed, 76.3% boys. The time from symptoms to diagnosis was 12 ± 33.5 months and age at diagnosis was 8.9 ± 4.75 years. The most frequent indications for endoscopy were: dysphagia (38%), gastroesophageal reflux (31.2%), bolus impaction (24.4%), and failure to thrive (10.5%). Approximately 70.3% had failed proton pump inhibitor treatment. The foods found to be causative of EoE by elimination and rechallenge were milk (42%), egg (21.5%), wheat/gluten (10.9%), and peanut (9.9%). Elimination diets were used exclusively in 154 of 410 (37.5%), topical steroids without elimination diets in 52 of 410 (12.6%), both diet and steroids in 183 of 410 (44.6%), systemic steroids in 22 of 410 (5.3%), and esophageal dilation in 7 of 410 (1.7%). Patient refusal, shortage of endoscopy time, and reluctance to perform multiple endoscopies per patient were noted as factors justifying deviation from guidelines. CONCLUSIONS: In this "real world" pediatric European cohort, milk and egg were the most common allergens triggering EoE. Although high-dose proton pump inhibitor trials have increased, attempted PPI treatment is not universal.
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Dates et versions

hal-04415673 , version 1 (24-01-2024)

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Citer

Assaf Hoofien, Jorge A Dias, Monica Malamisura, Francesca Rea, Sonny Chong, et al.. Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER).. Journal of Pediatric Gastroenterology and Nutrition, 2019, Journal of Pediatric Gastroenterology and Nutrition, 68, pp.552-558. ⟨10.1097/MPG.0000000000002215⟩. ⟨hal-04415673⟩

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