In Vitro Model of Human Trophoblast in Early Placentation. - Université de Lille Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Biomedicines Année : 2022

In Vitro Model of Human Trophoblast in Early Placentation.

D. Bačenková
  • Fonction : Auteur
M. Trebuňová
  • Fonction : Auteur
R. Hudák
  • Fonction : Auteur
E. Dosedla
  • Fonction : Auteur
A. Findrik-Balogová
  • Fonction : Auteur
J. Živčák
  • Fonction : Auteur


The complex process of placental implantation and development affects trophoblast progenitors and uterine cells through the regulation of transcription factors, cytokines, adhesion receptors and their ligands. Differentiation of trophoblast precursors in the trophectoderm of early ontogenesis, caused by the transcription factors, such as CDX2, TEAD4, Eomes and GATA3, leads to the formation of cytotrophoblast and syncytiotrophoblast populations. The molecular mechanisms involved in placental formation inside the human body along with the specification and differentiation of trophoblast cell lines are, mostly due to the lack of suitable cell models, not sufficiently elucidated. This review is an evaluation of current technologies, which are used to study the behavior of human trophoblasts and other placental cells, as well as their ability to represent physiological conditions both in vivo and in vitro. An in vitro 3D model with a characteristic phenotype is of great benefit for the study of placental physiology. At the same time, it provides great support for future modeling of placental disease.
Fichier principal
Vignette du fichier
biomedicines-10-00904.pdf (1.36 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04423832 , version 1 (29-01-2024)




D. Bačenková, M. Trebuňová, Dasa Cizkova, R. Hudák, E. Dosedla, et al.. In Vitro Model of Human Trophoblast in Early Placentation.. Biomedicines, 2022, Biomedicines, 10, ⟨10.3390/biomedicines10040904⟩. ⟨hal-04423832⟩


3 Consultations
2 Téléchargements



Gmail Mastodon Facebook X LinkedIn More