Cyclophosphamide versus Etoposide in Combination with Total Body Irradiation as Conditioning Regimen for Adult Patients with Ph-negative Acute Lymphoblastic Leukemia Undergoing Allogeneic Stem Cell Transplant: On behalf of the ALWP of the EBMT. - Université de Lille Accéder directement au contenu
Article Dans Une Revue American Journal of Hematology Année : 2018

Cyclophosphamide versus Etoposide in Combination with Total Body Irradiation as Conditioning Regimen for Adult Patients with Ph-negative Acute Lymphoblastic Leukemia Undergoing Allogeneic Stem Cell Transplant: On behalf of the ALWP of the EBMT.

Anna Czyz
  • Fonction : Auteur
Myriam Labopin
  • Fonction : Auteur
Sebastian Giebel
  • Fonction : Auteur
Gerard Socie
  • Fonction : Auteur
Jane Apperley
  • Fonction : Auteur
Liisa Volin
  • Fonction : Auteur
Peter Remenyi
  • Fonction : Auteur
Kim Orchard
  • Fonction : Auteur
Mauricette Michallet
  • Fonction : Auteur
Gernot Stuhler
  • Fonction : Auteur
Sridhar Chaganti
  • Fonction : Auteur
Martin Murray
  • Fonction : Auteur
Mahmoud Aljurf
  • Fonction : Auteur
Adrian Bloor
  • Fonction : Auteur
Jakob Passweg
  • Fonction : Auteur
Jurgen Finke
  • Fonction : Auteur
Mohamad Mohty
  • Fonction : Auteur
Arnon Nagler
  • Fonction : Auteur

Résumé

Allogeneic hematopoietic cell transplantation (alloHCT) with myeloablative conditioning based on total body irradiation (TBI) is widely used for the treatment of adults with acute lymphoblastic leukemia (ALL). TBI is most frequently administered in combination with either cyclophosphamide (Cy/TBI) or etoposide (Vp/TBI). The goal of this study was to retrospectively compare these two regimens. Adult patients with Ph-negative ALL treated with alloHCT in first or second complete remission who received Cy/TBI (n = 1346) or Vp/TBI (n = 152) conditioning were included in the analysis. In a univariate analysis, as compared to Cy/TBI, the use of Vp/TBI was associated with reduced incidence of relapse (17% vs. 30% at 5 years, P = .007), increased rate of leukemia-free survival (60% vs. 50%, P = .04), and improved

Dates et versions

hal-04425469 , version 1 (30-01-2024)

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Citer

Anna Czyz, Myriam Labopin, Sebastian Giebel, Gerard Socie, Jane Apperley, et al.. Cyclophosphamide versus Etoposide in Combination with Total Body Irradiation as Conditioning Regimen for Adult Patients with Ph-negative Acute Lymphoblastic Leukemia Undergoing Allogeneic Stem Cell Transplant: On behalf of the ALWP of the EBMT.. American Journal of Hematology, 2018, American Journal of Hematology, 93, pp.778-785. ⟨10.1002/ajh.25091⟩. ⟨hal-04425469⟩

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