Allogeneic stem cell transplantation using hla-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: a study from the acute leukemia working party of the ebmt - Université de Lille Accéder directement au contenu
Article Dans Une Revue Haematologica Année : 2019

Allogeneic stem cell transplantation using hla-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: a study from the acute leukemia working party of the ebmt

Résumé

Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation. However, -5/5q- is frequently associated with other high-risk cytogenetic aberrations such as complex karyotype, monosomal karyotype, monosomy 7 (-7), or 17p abnormalities (abn (17p)), the significance of which is unknown. In order to address this question, we studied adult patients with AML harboring -5/5q- having their first allogeneic transplantation between 2000 and 2015. Five hundred and one patients with -5/5q- have been analyzed. Three hundred and thirty-eight patients (67%) were in first remission and 142 (28%) had an active disease at time of allogeneic transplantation. The 2-year probabilities of overall survival and leukemia-free survival were 27% and 20%, respectively. The 2-year probability of treatment-related mortality was 20%. We identified four different cytogenetic groups according to additional abnormalities with prognostic impact: -5/5q- without complex karyotype, monosomal karyotype or abn(17p), -5/5q- within a complex karyotype, -5/5q- within a monosomal karyotype and the combination of -5/5q- with abn(17p). In multivariate analysis, factors associated with worse overall survival and leukemia-free survival across the four groups were active disease, age, monosomal karyotype, and abn(17p). The presence of -5/5q- without monosomal karyotype or abn(17p) was associated with a significantly better survival rate while -5/5q- in conjunction with monosomal karyotype or abn(17p) translated into a worse outcome. The patients harboring the combination of -5/5q- with abn(17p) showed very limited benefit from allogeneic transplantation.
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hal-04426904 , version 1 (30-01-2024)

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Xavier Poire, Myriam Labopin, Emmanuelle Polge, Edouard Forcade, Arnold Ganser, et al.. Allogeneic stem cell transplantation using hla-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: a study from the acute leukemia working party of the ebmt. Haematologica, 2019, Haematologica, 105, ⟨10.3324/haematol.2019.216168⟩. ⟨hal-04426904⟩
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