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Article Dans Une Revue (Article De Synthèse) Lupus science & medicine Année : 2020

Outcomes of pregnancy and associated factors in sub-saharan african women with systemic lupus erythematosus: a scoping review

Résumé

To scope and summarise available literature on the outcomes of pregnancy and associated factors in sub-Saharan African women with SLE. Electronic databases and reference lists of retrieved articles were searched to identify relevant studies published from 1 January 2000 to 28 October 2019. Data were combined through narrative synthesis. We included four studies retrospectively reporting a total of 137 pregnancies in 102 women over a 26-year period. Mean age at conception ranged from 27.2 to 39.9 years. Kidney damage, the predominant organ manifestation before conception, was reported in 43 (42.2%) patients. Ninety-seven (70.8%) pregnancies resulted in 98 live births. SLE flares occurred in 44 (32.2%) pregnancies, mainly skin (20.4%) and renal (18.2%) flares. Major adverse pregnancy outcomes (APOs) were preterm birth 38.8%, low birth weight 29.8%, pregnancy loss 29.2% and pre-eclampsia 24.8%. The main factors associated with APOs were nephritis and SLE flares. Over two-thirds of pregnancies resulted in live birth in this cohort of sub-Saharan African women with SLE. The main APOs and associated factors described in other parts of the world are also seen in this region, but with high rates of APOs. A large prospective multinational study is warranted for more compelling evidence.
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hal-04428586 , version 1 (31-01-2024)

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Mickael Essouma, Jan Rene Nkeck, Kodoume Motolouze, Jean Joel Bigna, Paul Tchaptchet, et al.. Outcomes of pregnancy and associated factors in sub-saharan african women with systemic lupus erythematosus: a scoping review. Lupus science & medicine, 2020, Lupus science & medicine, 7, ⟨10.1136/lupus-2020-000400⟩. ⟨hal-04428586⟩

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