A simple score to predict early death after kidney transplantation - Université de Lille Accéder directement au contenu
Article Dans Une Revue European Journal of Clinical Investigation Année : 2020

A simple score to predict early death after kidney transplantation

Résumé

BACKGROUND: Few studies have focused on risk stratification for premature death after transplantation. However, stratification of individual risk is an essential step in personalized care. METHODS: We have developed a risk score of early post-transplant death (ORLY score) in a prospective multicentre cohort including 942 patients and validated our model in a retrospective independent replication cohort including 874 patients. RESULTS: 60 patients (6.4%) from the prospective cohort died during the first three-year post-transplant. Age, male gender, diabetes, dialysis duration and chronic respiratory failure were associated with early post-transplant death. The multivariable model exhibited good discrimination ability (C-index = 0.78, 95%CI [0.75-0.81]). ORLY score highly predicted early death after transplantation (1.34; 95%CI, 1.22 to 1.48 for each increase of 1 point in score; P < .001). The predictive value of the score in the validation cohort was close to that observed in the experimental cohort (1.41; 95%CI, 1.27 to 1.56 for each increase of 1 point in score; P < .001). Merging the two cohorts, four categories of risk could be individualized: low, 0-5 (n = 522, mean risk, 1%); intermediate, 6-7 (n = 739, mean risk 4.7%); moderate, 8-10 (n = 429, mean risk 10%); and high risk 11-15 (n = 132, mean risk 19%). CONCLUSIONS: The ORLY score discriminates patients with high risk of early death.
Fichier non déposé

Dates et versions

hal-04431047 , version 1 (01-02-2024)

Identifiants

Citer

Jamal Bamoulid, Marie Frimat, Cecile Courivaud, Thomas Crepin, Emilie Gaiffe, et al.. A simple score to predict early death after kidney transplantation. European Journal of Clinical Investigation, 2020, European Journal of Clinical Investigation, pp.e13312. ⟨10.1111/eci.13312⟩. ⟨hal-04431047⟩
9 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More