Efficacy and safety of the local application of mitomycin c to recurrent oesophageal strictures in children - Université de Lille Accéder directement au contenu
Article Dans Une Revue Journal of Pediatric Gastroenterology and Nutrition Année : 2019

Efficacy and safety of the local application of mitomycin c to recurrent oesophageal strictures in children

Delphine Ley
  • Fonction : Auteur
Marie Bridenne
  • Fonction : Auteur
Julie Lemale
  • Fonction : Auteur
Bruno Hauser
  • Fonction : Auteur
Alain Lachaux
  • Fonction : Auteur
  • PersonId : 907892
Laurent Rebouissoux
  • Fonction : Auteur
Jerome Viala
  • Fonction : Auteur
Laurent Michaud
  • Fonction : Auteur

Résumé

Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children. This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90%) patients and multiple in 4 (10%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC. For 26 (67%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P < 0.0001). Sixteen (41%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC: single stenosis, short stenosis, and esophageal atresia type III. This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.

Dates et versions

hal-04441169 , version 1 (06-02-2024)

Identifiants

Citer

Delphine Ley, Marie Bridenne, Fréderic Gottrand, Julie Lemale, Bruno Hauser, et al.. Efficacy and safety of the local application of mitomycin c to recurrent oesophageal strictures in children. Journal of Pediatric Gastroenterology and Nutrition, 2019, Journal of Pediatric Gastroenterology and Nutrition, 69, pp.528-532. ⟨10.1097/MPG.0000000000002445⟩. ⟨hal-04441169⟩

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