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Article Dans Une Revue Pediatric Pulmonology Année : 2015

Reference Ranges for Shape Indices of the Flow-Volume Loop of Healthy Children

Résumé

BACKGROUND: The concavity of the descending limb of the maximum expiratory flow-volume loop (MEFVL) is the earliest change associated with airflow obstruction in small airways (ATS/ERS Task Force). The shape of the MEFVL changes with age but there are no reference values for shape indices for preschool and school children. OBJECTIVE: To define pediatric reference values for spirometric data and 3 shape indices of MEFVL: 2 geometric indices: the β angle i.e., the angle between the first ½ part and the 2nd part of the MEFVL and the forced expiratory flow after 50% of the forced vital capacity (FVC) has been exhaled/peak expiratory flow (FEF50 /PEF) ratio; and a ratio that describes relative growth between airway and lung parenchyma, the forced expiratory flow between 25 and 75% of FVC/FVC ratio (FEF25-75 /FVC ratio). METHODS: Data were obtained from 446 Caucasian children (2.5 to 15-year-old). The lambda, mu, sigma method was applied. RESULTS: References for spirometric parameters and 3 shape indices. The geometric indices decreased with age from 3 years of age (mean β angle was 215° and FEF50 /PEF ratio was 0.82) until 8 years of age (mean β angle was 191° and FEF50 /PEF ratio was 0.60) and then remained constant. The FEF25-75 /FVC ratio also decreased with age. Sex was a significant determinant for FEF25-75 /FVC ratio predicted values. CONCLUSIONS: This study provides standard reference equations for indices of mid-expiratory flows in children and we suggest using the FEF50 /PEF index.

Dates et versions

hal-04443027 , version 1 (07-02-2024)

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Véronique Nève, Jean-Louis Edme, Georges Baquet, Regis Matran. Reference Ranges for Shape Indices of the Flow-Volume Loop of Healthy Children. Pediatric Pulmonology, 2015, Pediatric pulmonology, 50, pp.1017-1024. ⟨10.1002/ppul.23112⟩. ⟨hal-04443027⟩
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