Caveolin-1 rs4730751 single-nucleotide polymorphism may not influence kidney transplant allograft survival - Université de Lille Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2019

Caveolin-1 rs4730751 single-nucleotide polymorphism may not influence kidney transplant allograft survival

Résumé

Caveolin-1 is a protein (encoded by the CAV1 gene) supposedly harboring a protective effect against fibrosis. CAV1 rs4730751 single nucleotide polymorphism (SNP) AA genotype was initially associated with lower graft survival compared to non-AA. However, subsequent studies could not find the same effect. CAV1 rs4730751 SNP was investigated on 918 kidney donors. Multivariate Cox-model analyses were performed to evaluate risk factors for graft loss. Longitudinal changes on long-term estimated glomerular filtration rate (eGFRs) were evaluated with a linear mixed model. Histopathological findings from protocolled biopsies after 3 months post transplantation were also analyzed. Donor CAV1 rs4730751 genotyping proportions were 7.1% for AA, 41.6% for AC and 51.3% for CC. The AA genotype, compared to non-AA, was not associated with lower graft survival censored or not for death (multivariate analysis: HR = 1.23 [0.74-2.05] and HR = 1.27 [0.84-1.92]). Linear mixed model on long-term eGFRs revealed also no significant difference according to the genotype, yet we observed a trend. AA genotype was also not associated with a higher degree of fibrosis index on protocolled kidney biopsies at 3 months. To conclude, donor CAV1 rs4730751 SNP may impact on kidney transplantation outcomes, but this study could not confirm this hypothesis.
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hal-04448369 , version 1 (09-02-2024)

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Mehdi Maanaoui, Remi Lenain, Aghiles Hamroun, Cynthia van der Hauwaert, Benjamin Lopez, et al.. Caveolin-1 rs4730751 single-nucleotide polymorphism may not influence kidney transplant allograft survival. Scientific Reports, 2019, Scientific Reports, 9, pp.15541. ⟨10.1038/s41598-019-52079-8⟩. ⟨hal-04448369⟩

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