Systematic review and meta-analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index - Université de Lille Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Alimentary Pharmacology and Therapeutics Année : 2018

Systematic review and meta-analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index

B Lo
  • Fonction : Auteur
V Prosberg M.
  • Fonction : Auteur
L Gluud L.
  • Fonction : Auteur
Wesley Chan
  • Fonction : Auteur
W Leong R.
  • Fonction : Auteur
E van der List
  • Fonction : Auteur
M van der Have
  • Fonction : Auteur
Laurent Peyrin-Biroulet
  • Fonction : Auteur
I Vind
  • Fonction : Auteur
Johan Burisch
  • Fonction : Auteur

Résumé

Background The Inflammatory Bowel Disease Disability Index (IBD-DI) has recently been developed for patients with Crohn's disease (CD) and ulcerative colitis (UC). Aim To assess the severity of disability and associated factors using the IBD-DI, and review the validity of the IBD-DI as a tool. Method Systematic review of cross-sectional studies. Patients included had UC or CD and were classified as active, in remission, or needing surgery, biological and/or steroid treatment. We included studies assessing disability using the IBD-DI and that were captured by electronic and manual searches (January 2017). The possibility of bias was evaluated with the Newcastle-Ottawa Scale. Results Nine studies were included with 3167 patients. Comparatively, patients with active disease had higher disability rates than those in remission (SMD [CI95] = 1.49[1.11, 1.88], I2 = 94%, P<.01), while patients on biological treatment had lower disability rates than those receiving corticosteroid treatment (SMD [CI95] = −0.22[−0.36, −0.08], I2 = 0%, P<.01). Disease activity and unemployment were found to be associated factors. The IBD-DI scored “good” for internal consistency, “fair” to “excellent” for intra-rater reliability and “excellent” for inter-rater reliability. Construct validity was “moderately strong” to “very strong” and structural validity was found to be mainly unidimensional. The IBD-DI had excellent responsiveness, while its interpretability was only useful on a group level. Conclusions This systematic review and meta-analysis found a significant association between disease activity, treatment received and disability; although significant heterogeneity was found. The IBD-DI is reliable and valid, but further studies are needed to measure its interpretability.

Dates et versions

hal-04452452 , version 1 (12-02-2024)

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Citer

B Lo, V Prosberg M., L Gluud L., Wesley Chan, W Leong R., et al.. Systematic review and meta-analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index. Alimentary Pharmacology and Therapeutics, 2018, Alimentary Pharmacology and Therapeutics, 47, pp.6-15. ⟨10.1111/apt.14373⟩. ⟨hal-04452452⟩

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