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Article Dans Une Revue Journal of breath research Année : 2018

Elevated alveolar nitric oxide is linked to poor aerobic capacity and chronotropic incompetence in liver transplant candidates

Résumé

Increased nitric oxide is involved in abnormal hemodynamic parameters and respiratory function of cirrhotic patients. We aimed to quantify partitioning exhaled nitric oxide measurements in exhaled air in liver transplantation (LT) candidates and evaluate their relationships with chronotropic incompetence and aerobic capacity. We compared exhaled nitric oxide (NO) measurements, heart rate response and peak oxygen uptake during incremental exercise in liver transplantation candidates to those of controls. As opposed to healthy control subjects, LT candidates displayed elevated alveolar NO, blunted chronotropic response and reduced V'O22-1-122 Increasing alveolar NO could be a specific pathophysiological condition limiting aerobic capacity in LT candidates.
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Dates et versions

hal-04459073 , version 1 (15-02-2024)

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Sebastien Hulo, Jean-Louis Edme, Jocelyn Inamo, Richard van Bulck, Sebastien Dharancy, et al.. Elevated alveolar nitric oxide is linked to poor aerobic capacity and chronotropic incompetence in liver transplant candidates. Journal of breath research, 2018, Journal of breath research, 12 (4), ⟨10.1088/1752-7163/aad847⟩. ⟨hal-04459073⟩

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