HbA1c at the time of testing for gestational diabetes identifies women at risk for pregnancy complications. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Diabetes & Metabolism Année : 2022

HbA1c at the time of testing for gestational diabetes identifies women at risk for pregnancy complications.

Résumé

Objective It is unclear whether glycated haemoglobin (HbA1c) has utility in predicting adverse outcomes in gestational diabetes mellitus (GDM). The aims of the study were to examine the predictive value of HbA1c at GDM diagnosis with adverse pregnancy outcomes. Research design and methods This was a cohort study of 4,383 women with GDM between 2011 and 2018. We assessed the association of HbA1c with pregnancy outcomes using logistic regression models before and after adjustment for predefined risk factors of GDM. We examined these associations considering HbA1c as categorical variables using five pre-specified HbA1c classes: and as a continuous variable. Results An HbA1c ≥ 5.6% (38 mmol/mol) identified women with at greater risk for macrosomia: odds ratio (OR) [95% confidence interval] = 2.12 [1.29; 3.46] for HbA1c = 5.6-5.9% and 2.06 [1.14; 3.70] for HbA1c > 5.9% versus HbA1c ≤ 4.5% (26 mmol/mol). Similarly, HbA1c ≥ 5.6% (38 mmol/mol) was associated with greater risk for caesarean: 1.64 [1.06; 2.53] for HbA1c = 5.6-5.9% and 1.58 [0.93; 2.7] for HbA1c > 5.9% (41 mmol/mol) versus HbA1c ≤ 4.5% (26 mmol/mol). Using HbA1c ≤ 4.5% (26 mmol/mol) as reference category, HbA1c > 5.9% (41 mmol/mol) increased the OR of preterm delivery to 3.33 [1.27; 8.71]. HbA1c remained significant for Adverse Pregnancy Outcome Composite after adjustment (P < 0.0001). Discussion Our finding suggests that a single HbA1c reading may be a useful pragmatic tool to identify women at risk. Such identification may be a useful guide for identifying and applying preventative treatment for women at increased risk.
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Dates et versions

hal-04470281 , version 1 (21-02-2024)

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Citer

F. Barbry, Madleen Lemaitre, Camille Ternynck, H. Wallet, M Cazaubiel, et al.. HbA1c at the time of testing for gestational diabetes identifies women at risk for pregnancy complications.. Diabetes & Metabolism, 2022, Diabetes & Metabolism, 48 (3), pp.101313. ⟨10.1016/j.diabet.2021.101313⟩. ⟨hal-04470281⟩
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