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Article Dans Une Revue Journal of Medical Virology Année : 2019

Routine drug resistance testing in proviral hiv-1 dna: prevalence of stop codons and hypermutation, and associated factors

Résumé

We investigated the presence of stop codons (SC) and/or hypermutation (HM) in HIV-1 DNA sequences generated for routine drug resistance testing in proviral HIV-1 DNA, and sought for associated factors. At least one SC was identified in 6.2% of HIV-1 DNA sequences, among which 54.8% were hypermutated. The defective virus group (SC w/o HM) was similar to the non-SC group regarding the characteristics of HIV-1 infection, and before drug exposure. In addition, the HIV-1 DNA levels were not different between both groups. Sequences with SC/HM displayed a higher proportion of RAMs. The impact of the SC/HM associated RAMs on clinical responses requires further investigation.
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hal-04474412 , version 1 (23-02-2024)

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Enagnon Kazali Alidjinou, Josephine Deldalle, Olivier Robineau, Christophe Hallaert, Agnes Meybeck, et al.. Routine drug resistance testing in proviral hiv-1 dna: prevalence of stop codons and hypermutation, and associated factors. Journal of Medical Virology, 2019, Journal of medical virology, 91 (9), pp.1684-1687. ⟨10.1002/jmv.25474⟩. ⟨hal-04474412⟩

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