Exposure to metal fumes and circulating mirnas in algerian welders - Université de Lille Accéder directement au contenu
Article Dans Une Revue International Archives of Occupational and Environmental Health Année : 2019

Exposure to metal fumes and circulating mirnas in algerian welders

Résumé

A cross-sectional study was conducted in a group of Algerian welders to study the relationship between the exposure to metal particles from welding fumes and the concentration of three circulating miRNAs, miR-21, miR-146a and miR-155, as markers of renal function injury. Characteristics of the subjects and the curriculum laboris were determined by questionnaires. We measured the concentrations of metals in blood and urine samples using ICP-MS. The three circulating miRNAs studied were measured by quantitative PCR. Associations between miRNAs and internal exposure markers were assessed by simple and multiple regression analyses. miR-21 was significantly lower among welders (p = 0.017), compared with controls, adjusted for age, body mass index, smoking status and seniority. Significant adjusted associations were observed between miR-21 or miR-155 and urinary chromium (p = 0.005 or p = 0.041, respectively), miR-146a and urinary nickel (p = 0.019). The results of the multivariate analysis showed that duration of employment was the main factor responsible for the variation of miRNAs among welders. In conclusion, a recent exposure to certain metals, mainly chromium and nickel, appears to be associated to a decrease in plasma expression of miR-21, miR-146a and miR-155. Further larger studies would help to determine the mechanisms of action of metal particles on miRNA expression.
Fichier non déposé

Dates et versions

hal-04481539 , version 1 (28-02-2024)

Identifiants

Citer

Imene Amrani, Nahida Haddam, Anne Garat, Delphine Allorge, Farid Zerimech, et al.. Exposure to metal fumes and circulating mirnas in algerian welders. International Archives of Occupational and Environmental Health, 2019, International Archives of Occupational and Environmental Health, 93, pp.553-561. ⟨10.1007/s00420-019-01509-1⟩. ⟨hal-04481539⟩

Collections

UNIV-LILLE
2 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More