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Article Dans Une Revue (Article De Synthèse) Mucosal Immunology Année : 2021

Comment on \"ilc1 drive intestinal epithelial and matrix remodeling\"

Résumé

Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. (Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC1 could promote intestinal epithelial growth and tissue remodeling through an unexpected mechanism that involves the transforming growth factor 1 (TGF-β1) and the metalloproteinase MMP9.
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Dates et versions

hal-04490130 , version 1 (05-03-2024)

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Fatima Hariss, Bertrand Meresse. Comment on \"ilc1 drive intestinal epithelial and matrix remodeling\". Mucosal Immunology, 2021, Mucosal Immunology, ⟨10.1038/s41385-020-00360-9⟩. ⟨hal-04490130⟩

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