Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT).
Mohamad Mohty
(1)
,
Florent Malard
(1)
,
Ahmed S. Alaskar
(2)
,
Mahmoud Aljurf
(3)
,
Mutlu Arat
,
Peter Bader
(4)
,
Frederic Baron
(5)
,
Ali Bazarbachi
(6)
,
Didier Blaise
(7)
,
Eolia Brissot
(1)
,
Fabio Ciceri
(8)
,
Selim Corbacioglu
(9)
,
Jean-Hugues Dalle
(10)
,
Fiona Dignan
(11)
,
Anne Huynh
(12)
,
Michelle Kenyon
(13)
,
Arnon Nagler
(14)
,
Antonio Pagliuca
(13)
,
Zinaida Peric
(15)
,
Paul G. Richardson
(16)
,
Annalisa Ruggeri
(8)
,
Tapani Ruutu
(17)
,
Ibrahim Yakoub-Agha
(18)
,
Enric Carreras
(19)
1
CHU Saint-Antoine [AP-HP]
2 KAIMRC - King Abdullah International Medical Research Center [Riyadh]
3 KFSHRC - King Faisal Specialist Hospital and Resarch Centre [Riyadh, Saudi Arabia]
4 Goethe University Frankfurt
5 Université de Liège
6 AUB - American University of Beirut [Beyrouth]
7 IPC - Institut Paoli-Calmettes
8 San Raffaele Scientific Institute
9 University of Regensburg
10 Hôpital Robert Debré
11 University of Manchester [Manchester]
12 Service Hématologie - IUCT-Oncopole [CHU Toulouse]
13 KCH - King's College Hospital
14 Chaim Sheba Medical Center
15 University Hospital Centre Zagreb
16 Mayo Clinic
17 HUS - Helsinki University Hospital [Finland]
18 LIRIC - Lille Inflammation Research International Center - U 995
19 UB - Universitat de Barcelona
2 KAIMRC - King Abdullah International Medical Research Center [Riyadh]
3 KFSHRC - King Faisal Specialist Hospital and Resarch Centre [Riyadh, Saudi Arabia]
4 Goethe University Frankfurt
5 Université de Liège
6 AUB - American University of Beirut [Beyrouth]
7 IPC - Institut Paoli-Calmettes
8 San Raffaele Scientific Institute
9 University of Regensburg
10 Hôpital Robert Debré
11 University of Manchester [Manchester]
12 Service Hématologie - IUCT-Oncopole [CHU Toulouse]
13 KCH - King's College Hospital
14 Chaim Sheba Medical Center
15 University Hospital Centre Zagreb
16 Mayo Clinic
17 HUS - Helsinki University Hospital [Finland]
18 LIRIC - Lille Inflammation Research International Center - U 995
19 UB - Universitat de Barcelona
Mutlu Arat
- Fonction : Auteur
Frederic Baron
- Fonction : Auteur
- PersonId : 771344
- ORCID : 0000-0002-2944-3812
- IdRef : 184756278
Eolia Brissot
- Fonction : Auteur
- PersonId : 1098504
- ORCID : 0000-0003-4471-418X
Résumé
Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.