Efficacy and safety of sm-153-edtmp as treatment of painful bone metastasis: a large single-center study - Université de Lille Accéder directement au contenu
Article Dans Une Revue Supportive Care in Cancer Année : 2018

Efficacy and safety of sm-153-edtmp as treatment of painful bone metastasis: a large single-center study

Résumé

Purpose The purpose of this study is to assess the efficacy of 153Sm-EDTMP (Quadramet®) in a clinical setting. Methods We have conducted a retrospective study of all consecutive patients (pts) treated with 153Sm-EDTMP for painful bone metastases. At each visit (before and after treatment), four parameters were collected: (i) pain assessment according to the 10-step visual analogue scale (VAS), (ii) sleep disturbance related to pain, (iii) dose of analgesic medication, and (iv) answer to the following closed question “Do you think you obtained a benefit from treatment?” Success of treatment was defined by the combination of these four parameters. Results Three hundred seventy consecutive 153Sm-EDTMP treatments for painful bone metastases were given. Patients had the following primary tumors: breast carcinoma (153), prostate carcinoma (155), lung carcinoma (27), or other cancers (35). Fifty-eight percent of the patients had received previous external osseous radiotherapy. Ninety-seven percent of the patients were treated with concomitant analgesics and 61% were treated with diphosphonates. A clinical benefit was described in 55.0% of cases at D30. Treatment was more effective in cases of breast and prostate cancers compared with other types of primary cancers. Patients described a benefit at D30 in 62, 58, 6, and 38% of cases of breast, prostate, lung, and other cancers. The subjective efficacy was accompanied by a decrease in analgesic intake in 35.0% of cases. Conclusion 153Sm-EDTMP therapy is an effective supportive treatment in patients who suffer from bone metastases, especially in patients with breast or prostate cancer.
Fichier non déposé

Dates et versions

hal-04491551 , version 1 (06-03-2024)

Identifiants

Citer

Helene Kolesnikov-Gauthier, Nathalie Lemoine, Emmanuelle Tresch-Bruneel, Anais Olivier, Aurore Oudoux, et al.. Efficacy and safety of sm-153-edtmp as treatment of painful bone metastasis: a large single-center study. Supportive Care in Cancer, 2018, Supportive care in cancer official journal of the Multinational Association of Supportive Care in Cancer, 26, pp.751-758. ⟨10.1007/s00520-017-3885-3⟩. ⟨hal-04491551⟩

Collections

UNIV-LILLE
3 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More