Trends in outcome of transplantation in patients with secondary acute myeloid leukemia: an analysis from the Acute Leukemia Working Party (ALWP) of the EBMT. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Bone Marrow Transplantation Année : 2022

Trends in outcome of transplantation in patients with secondary acute myeloid leukemia: an analysis from the Acute Leukemia Working Party (ALWP) of the EBMT.

Résumé

Trends in outcome of transplantation (HSCT) in secondary acute myeloid leukemia (sAML) are limited. We evaluated results of HSCT in 4224 patients with sAML in complete remission; 1337 were transplanted in 2000–2010 and 2887 in 2011–2020. Median age was 54 (range, 18–74) and 59 (range, 18–78) years, respectively (p < 0.0001). Donors were MSD in 65% vs. 37%, 10/10 UD in 27% vs. 50%, and 9/10 UD in 8% vs. 13%, respectively (p < 0.0001). Conditioning was myeloablative in 46% and 38%, respectively. Two-year non-relapse mortality (NRM) was lower in patients transplanted in 2011–2020 vs. those transplanted in 2000–2010, 18% vs. 21% (hazard ratio (HR) = 0.82, 95% CI: 0.68–0.9; p = 0.04) and modified GVHD-free, relapse-free survival (GRFS) (HR = 0.9, 95% CI: 0.81–0.99; p = 0.04) was better in patients transplanted in the 2011–2020 vs. those transplanted in 2000–2010. Two-year relapse incidence (RI) was similar between the 2 groups with 32% vs. 31%, (HR = 1.05, 95% CI: 0.9–1.22; p = 0.55). Likewise, leukemia-free survival (LFS) (HR = 0.95, 95% CI: 0.84–1.07; p = 0.38) and overall survival (OS) (HR = 0.93, 95% CI: 0.82–1.05; p = 0.26) were not significantly different between the two periods. In conclusion, Incidence of NRM has been significantly reduced and GRFS significantly increased in HSCT for sAML in the last 2 decades.
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Dates et versions

hal-04499486 , version 1 (11-03-2024)

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A. Nagler, Maud Ngoya, Jacques-Emmanuel Galimard, Myriam Labopin, N. Kröger, et al.. Trends in outcome of transplantation in patients with secondary acute myeloid leukemia: an analysis from the Acute Leukemia Working Party (ALWP) of the EBMT.. Bone Marrow Transplantation, 2022, Bone Marrow Transplantation, 57, pp.1788-1796. ⟨10.1038/s41409-022-01825-0⟩. ⟨hal-04499486⟩
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