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Article Dans Une Revue Current Research in Translational Medicine Année : 2019

An international survey on the management of patients receiving car t-cell therapy for haematological malignancies on behalf of the chronic malignancies working party of ebmt

P. J. Hayden
  • Fonction : Auteur
T. Sirait
  • Fonction : Auteur
Linda Koster
  • Fonction : Auteur
John A. Snowden
  • Fonction : Auteur

Résumé

Two chimeric antigen receptor (CAR) T-cell therapies - Tisagenlecleucel (Kymriah™™ An online survey with a dual focus on (1) 'real world' patient eligibility criteria and (2) models of care for patient follow-up was sent to experienced physicians. There were 41 respondents (10 countries) and 93% worked in FACT-JACIE-accredited transplant centres. Most felt that a history of malignancy (57%), prior allo-HCT for B-NHL (78%-81%) and prior treatment with anti-CD19/CD3 BiTE antibodies (76%-86%) do not constitute contra-indications to CAR T therapy. Clinicians were divided as to whether CNS involvement represented an exclusion criterion. There was agreement that patients with viral infections (HIV, Hepatitis B or Hepatitis C) are not eligible. There is no common model of care for long-term follow-up. Most respondents believed that patients should attend the hospital two (43%) to three (33%) times weekly during the first month following discharge. A majority (69%) of respondents work in centres where there is an MDT meeting with a specific focus on follow-up following CAR T Therapy. Follow-up care is currently delivered either in HCT or haematology-oncology outpatient clinics. The responses reveal wide variation in perceived patient eligibility criteria and highlight the need for consensus guidelines. The findings also illustrate the embryonic nature of current follow-up arrangements.
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hal-04517445 , version 1 (22-03-2024)

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P. J. Hayden, T. Sirait, Linda Koster, John A. Snowden, Ibrahim Yakoub-Agha. An international survey on the management of patients receiving car t-cell therapy for haematological malignancies on behalf of the chronic malignancies working party of ebmt. Current Research in Translational Medicine, 2019, Current Research in Translational Medicine, 67, pp.79-88. ⟨10.1016/j.retram.2019.05.002⟩. ⟨hal-04517445⟩

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