New indices in predicting cardiometabolic risk and its relation to endothelial dysfunction in adolescents: The HELENA study. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Nutrition, Metabolism and Cardiovascular Diseases Année : 2023

New indices in predicting cardiometabolic risk and its relation to endothelial dysfunction in adolescents: The HELENA study.

Résumé

Background and aims Blood pressure (BP) changes and insulin resistance (IR) are important cardiometabolic risk (CMR) factors; their early identification can contribute to the reduction of cardiovascular events in adulthood. This necessitates the search for more accessible and easily applied indicators for their prediction. Therefore, this study aimed to evaluate the predictive power of the indices, TyG, TG/HDL-c, height-corrected lipid accumulation product (HLAP), and visceral adiposity index (VAI), in identifying the CMR obtained by high BP and IR and to verify their relationship with biomarkers of endothelial dysfunction (ED) in European adolescents. Methods and results The anthropometric data and blood biomarkers of 744 adolescents (343 boys and 401 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study (HELENA-CSS), with a mean age of 14.67 (SD 1.15) years, were assessed. The adolescents were then classified according to the presence or absence of high BP and IR. The cut-off points of the indices evaluated for the identification of CMR were determined. The relationship between CMR diagnosed using these indices and ED biomarkers was tested. The HLAP and TG/HDL-c were fair predictors of CMR obtained by IR in male adolescents. These indices showed association with hsCRP in sVCAM-1 in boys, but it lost significance after adjusting for age and body mass index. Conclusion TG/HDL-c and HLAP indices showed a fair performance in predicting CMR, obtained by IR, in male adolescents. ED showed no association with the CMR identified by the indices.
Fichier non déposé

Dates et versions

hal-04519933 , version 1 (25-03-2024)

Identifiants

Citer

Maria D. A. Nogueira, Ribanna A. M. Braga, Yannis Manios, Odysseas Androutsos, Dénes Molnár, et al.. New indices in predicting cardiometabolic risk and its relation to endothelial dysfunction in adolescents: The HELENA study.. Nutrition, Metabolism and Cardiovascular Diseases, 2023, Nutrition, Metabolism and Cardiovascular Diseases, ⟨10.1016/j.numecd.2023.01.015⟩. ⟨hal-04519933⟩

Collections

RIIP UNIV-LILLE
2 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More