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Article Dans Une Revue Journal of Pediatric Endocrinology and Metabolism Année : 2022

Developing a risk assessment tool for identifying individuals at high risk for developing insulin resistance in European adolescents: the HELENA-IR score.

Katerina Kondakis
  • Fonction : Auteur
Evangelina Grammatikaki
  • Fonction : Auteur
Marios Kondakis
  • Fonction : Auteur
Denes Molnar
  • Fonction : Auteur
Sonia Gómez-Martínez
  • Fonction : Auteur
Marcela González-Gross
  • Fonction : Auteur
Anthony Kafatos
  • Fonction : Auteur
Yannis Manios
  • Fonction : Auteur
David Jiménez Pavón
  • Fonction : Auteur
Mathilde Kersting
  • Fonction : Auteur
Manuel J. Castillo
  • Fonction : Auteur
Luis A. Moreno
  • Fonction : Auteur
Stefaan de Henauw
  • Fonction : Auteur

Résumé

Objectives To develop and validate an easy-to-use screening tool for identifying adolescents at high-risk for insulin resistance (IR). Methods Α total of 1,053 adolescents (554 females), aged 12.5 to 17.5 years with complete data on glucose and insulin levels were included. Body mass index (BMI), fat mass index (FMI) and the homeostasis model assessment for insulin resistance (HOMA-IR) were calculated. VO2max was predicted using 20 m multi-stage fitness test. The population was randomly separated into two cohorts for the development (n=702) and validation (n=351) of the index, respectively. Factors associated with high HOMA-IR were identified by Spearman correlation in the development cohort; multiple logistic regression was performed for all identified independent factors to develop a score index. Finally, receiver operating characteristic (ROC) analysis was performed in the validation cohort and was used to define the cut-off values that could identify adolescents above the 75th and the 95th percentile for HOMA-IR. Results BMI and VO2max significantly identified high HOMA-IR in males; and FMI, TV watching and VO2max in females. The HELENA-IR index scores range from 0 to 29 for males and 0 to 43 for females. The Area Under the Curve, sensitivity and specificity for identifying males above the 75th and 95th of HOMA-IR percentiles were 0.635 (95%CI: 0.542–0.725), 0.513 and 0.735, and 0.714 (95%CI: 0.499–0.728), 0.625 and 0.905, respectively. For females, the corresponding values were 0.632 (95%CI: 0.538–0.725), 0.568 and 0.652, and 0.708 (95%CI: 0.559–0.725), 0.667 and 0.617, respectively. Simple algorithms were created using the index cut-off scores. Conclusions Paediatricians or physical education teachers can use easy-to-obtain and non-invasive measures to apply the HELENA-IR score and identify adolescents at high risk for IR, who should be referred for further tests.
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Dates et versions

hal-04521291 , version 1 (26-03-2024)

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Katerina Kondakis, Evangelina Grammatikaki, Marios Kondakis, Denes Molnar, Sonia Gómez-Martínez, et al.. Developing a risk assessment tool for identifying individuals at high risk for developing insulin resistance in European adolescents: the HELENA-IR score.. Journal of Pediatric Endocrinology and Metabolism, 2022, Journal of Pediatric Endocrinology and Metabolism, ⟨10.1515/jpem-2022-0265⟩. ⟨hal-04521291⟩

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