Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier - Université de Lille Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2006

Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier

Résumé

Co-incubations of various β-cyclodextrins and doxorubicin have been evaluated on an in vitro model of blood–brain barrier in order to increase the delivery of this P-gp substrate to the brain. Among these cyclodextrins used, the Rame-β-cyclodextrin and Crysme-β-cyclodextrin increased the transport by a factor of 2 and 3.7, respectively. This increase was attributed to the cholesterol extraction property of these cyclodextrins from brain capillary endothelial cells leading to a modulation of the P-gp activity.

Domaines

Chimie

Dates et versions

hal-04559270 , version 1 (25-04-2024)

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Citer

Sebastien Tilloy, Véronique Monnaert, Laurence Fenart, Herve Bricout, Roméo Cecchelli, et al.. Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier. Bioorganic and Medicinal Chemistry Letters, 2006, Bioorganic and Medicinal Chemistry Letters, 16, pp.2154-2157. ⟨10.1016/j.bmcl.2006.01.049⟩. ⟨hal-04559270⟩
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