Coumarin-poly(2-oxazoline)s as synergetic and protein-undetected nanovectors for photodynamic therapy - Université de Lille Accéder directement au contenu
Article Dans Une Revue International Journal of Pharmaceutics Année : 2024

Coumarin-poly(2-oxazoline)s as synergetic and protein-undetected nanovectors for photodynamic therapy

Résumé

Because of the difficult challenges of nanopharmaceutics, the development of a variety of nanovectors is still highly desired. Photodynamic therapy, which uses a photosensitizer to locally produce reactive oxygen species to kill the undesired cells, is a typical example for which encapsulation has been shown to be beneficial. The present work describes the use of coumarin-functionalized polymeric nanovectors based on the self-assembly of amphiphilic poly(2-oxazoline)s. Encapsulation of pheophorbide a, a known PDT photosensitizer, is shown to lead to an increased efficiency compared to the un-encapsulated version. Interestingly, the presence of coumarin both enhances the desired photocytotoxicity and enables the crosslinking of the vectors. Various nanovectors are examined, differing by their size, shape and hydrophilicity. Their behaviour in PDT protocols on HCT-116 cells monolayers is described, the influence of their crosslinking commented. Furthermore, the formation of a protein corona is assessed.
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Dates et versions

hal-04573347 , version 1 (13-05-2024)

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Diana Heaugwane, Orélia Cerlati, Kedafi Belkhir, Tarek Benkhaled, Sylvain Catrouillet, et al.. Coumarin-poly(2-oxazoline)s as synergetic and protein-undetected nanovectors for photodynamic therapy. International Journal of Pharmaceutics, 2024, International Journal of Pharmaceutics, 658, pp.124186. ⟨10.1016/j.ijpharm.2024.124186⟩. ⟨hal-04573347⟩
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