The hypothalamic-pituitary-gonadal axis and the enigma of Alzheimer disease sex differences. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Nature Reviews Endocrinology Année : 2024

The hypothalamic-pituitary-gonadal axis and the enigma of Alzheimer disease sex differences.

Résumé

Alzheimer disease has a sex bias: women are twice as likely as men to be affected. Studies have linked elevated follicle-stimulating hormone (FSH) levels to worsened Alzheimer disease pathology and cognitive decline in mice. Exploring the interaction of FSH with APOE4 has uncovered new aspects of Alzheimer disease. The therapeutic potential of FSH and gonadotropin-releasing hormone have also been highlighted.
Fichier non déposé

Dates et versions

hal-04598715 , version 1 (03-06-2024)

Identifiants

Citer

Florent Sauve, Loïc Kacimi, Vincent Prevot. The hypothalamic-pituitary-gonadal axis and the enigma of Alzheimer disease sex differences.. Nature Reviews Endocrinology, 2024, Nature Reviews Endocrinology, 20, pp.317-318. ⟨10.1038/s41574-024-00981-1⟩. ⟨hal-04598715⟩

Collections

UNIV-LILLE
5 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More