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Article Dans Une Revue (Article De Synthèse) Frontiers in Medicine Année : 2017

Protein Translation and Signaling in Human Eosinophils

Résumé

We have recently reported that, unlike IL-5 and GM-CSF, IL-3 induces increased translation of a subset of mRNAs. In addition, we have demonstrated that Pin1 controls the activity of mRNA binding proteins, leading to enhanced mRNA stability, GM-CSF protein production and prolonged eosinophil (EOS) survival. In this review, discussion will include an overview of cap-dependent protein translation and its regulation by intracellular signaling pathways. We will address the more general process of mRNA post-transcriptional regulation, especially regarding mRNA binding proteins, which are critical effectors of protein translation. Furthermore, we will focus on (1) the roles of IL-3-driven sustained signaling on enhanced protein translation in EOS, (2) the mechanisms regulating mRNA binding proteins activity in EOS, and (3) the potential targeting of IL-3 signaling and the signaling leading to mRNA binding activity changes to identify therapeutic targets to treat EOS-associated diseases.
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hal-04614196 , version 1 (17-06-2024)

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Stéphane Esnault, Zhong-Jian Shen, James S Malter. Protein Translation and Signaling in Human Eosinophils. Frontiers in Medicine, 2017, Frontiers in Medicine, 4, pp.150. ⟨10.3389/fmed.2017.00150⟩. ⟨hal-04614196⟩

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