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Article Dans Une Revue (Article De Synthèse) International Journal of Clinical and Experimental Pathology Année : 2008

Thymic stromal lymphopoietin (TSLP) as a bridge between infection and atopy

Résumé

The rising worldwide prevalence of asthma has intensified interest in the natural history of asthma. An improved understanding of the genetic, environmental, and developmental factors contributing to the inception and exacerbation of asthma will be crucial to efforts to devise effective preventive and therapeutic interventions. There is increasing evidence that the complex interplay of early life respiratory viral infections and allergic sensitization is important in the development of asthma. Major causes of asthma exacerbations are respiratory viral infections and aeroallergen exposure, which may have interactive co-morbid effects. This review describes the potential role of thymic stromal lymphopoietin (TSLP) as a connection between the innate immune response to respiratory viral infections and the type-2 adaptive immune response in the development and exacerbation of asthma.
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Dates et versions

hal-04614243 , version 1 (17-06-2024)

Identifiants

  • HAL Id : hal-04614243 , version 1
  • PUBMED : 18787616

Citer

Stéphane Esnault, Louis A Rosenthal, Deng-Shun Wang, James S Malter. Thymic stromal lymphopoietin (TSLP) as a bridge between infection and atopy. International Journal of Clinical and Experimental Pathology, 2008, International Journal of Clinical and Experimental Pathology, 1, pp.325-30. ⟨hal-04614243⟩

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