Results and perinatal outcomes from 189 ICSI cycles of couples with asthenozoospermic men and flagellar defects assessed by transmission electron microscopy. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Reproductive BioMedicine Online Année : 2023

Results and perinatal outcomes from 189 ICSI cycles of couples with asthenozoospermic men and flagellar defects assessed by transmission electron microscopy.

Estelle Escudier
  • Fonction : Auteur
Marjorie Whitfield
  • Fonction : Auteur
Charles Coutton
  • Fonction : Auteur
Guillaume Martinez
  • Fonction : Auteur
Pierre F. Ray
  • Fonction : Auteur
Zine-Eddine Kherraf
  • Fonction : Auteur
Marie Legendre
  • Fonction : Auteur

Résumé

Research question Do patients presenting with flagella ultrastructural defects as assessed by electron microscopy, and defined within three phenotypes (dysplasia of the fibrous sheath [DFS], primary flagellar dyskinesia [PFD] and non-specific flagellar abnormalities [NSFA]), have decreased chances of success in intracytoplasmic sperm injection (ICSI) or adverse obstetric and neonatal outcomes? Design Retrospective analysis of 189 ICSI cycles from 80 men with spermatozoa flagellum ultrastructural defects (DFS [n = 16]; PFD [n = 14]; NSFA [n = 50] compared with a control group (n = 97). Cycles were cumulatively analysed. All fresh and frozen embryo transfers resulting from each ICSI attempt were included. The effect of transmission electron microscopy (TEM) phenotype on the main ICSI outcomes was assessed by a multivariate logistic regression combined with a generalized linear mixed model to account for the non-independence of the observations. Results No predictive value of TEM phenotype was found on the main outcomes of ICSI, namely fertilization rates, pregnancy and delivery rates, and cumulative pregnancy and delivery rates. Cumulative pregnancy rates ranged from 29.0–43.3% in the different TEM phenotype subgroups compared with 36.8% in the control group. Cumulative live birth rates ranged from 24.6–36.7% compared with 31.4% in the control group. No increase was found in miscarriages, preterm births, low birth weights or birth abnormalities. Conclusions Data on the cumulative chances of success in ICSI of patients with ultrastructural flagellar defects, a rare cause of male infertility often associated with an underlying genetic cause, are reassuring, as are obstetrical and neonatal outcomes in this population.
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hal-04630993 , version 1 (01-07-2024)

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Angele Boursier, Augustin Boudry, Valérie Mitchell, Anne Loyens, Nathalie Rives, et al.. Results and perinatal outcomes from 189 ICSI cycles of couples with asthenozoospermic men and flagellar defects assessed by transmission electron microscopy.. Reproductive BioMedicine Online, 2023, Reproductive BioMedicine Online, 47, pp.103328. ⟨10.1016/j.rbmo.2023.103328⟩. ⟨hal-04630993⟩
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