Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Stroke Année : 2022

Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.

A. Theodorou
  • Fonction : Auteur
L. Palaiodimou
  • Fonction : Auteur
K. Malhotra
  • Fonction : Auteur
C. Zompola
  • Fonction : Auteur
A. H. Katsanos
  • Fonction : Auteur
A. Shoamanesh
  • Fonction : Auteur
E. Boviatsis
  • Fonction : Auteur
E. Dardiotis
  • Fonction : Auteur
M. Spilioti
  • Fonction : Auteur
S. Sacco
  • Fonction : Auteur
D. J. Werring
  • Fonction : Auteur
A. V. Alexandrov
  • Fonction : Auteur
G. P. Paraskevas
  • Fonction : Auteur

Résumé

Background: There are limited data regarding the prevalence of distinct clinical, neuroimaging and genetic markers among patients diagnosed with cerebral amyloid angiopathy–related inflammation (CAA-ri). We sought to determine the prevalence of clinical, radiological, genetic and cerebrospinal fluid biomarker findings in patients with CAA-ri. Methods: A systematic review and meta-analysis of published studies including patients with CAA-ri was conducted to determine the prevalence of clinical, neuroimaging, genetic and cerebrospinal fluid biomarker findings. Subgroup analyses were performed based on (1) prospective or retrospective study design and (2) CAA-ri diagnosis with or without available biopsy. We pooled the prevalence rates using random-effects models and assessed the heterogeneity using Cochran-Q and I2-statistics. Results: We identified 4 prospective and 17 retrospective cohort studies comprising 378 patients with CAA-ri (mean age, 71.5 years; women, 52%). The pooled prevalence rates were as follows: cognitive decline at presentation 70% ([95% CI, 54%–84%]; I2=82%), focal neurological deficits 55% ([95% CI, 40%–70%]; I2=82%), encephalopathy 54% ([95% CI, 39%–68%]; I2=43%), seizures 37% ([95% CI, 27%–49%]; I2=65%), headache 31% ([95% CI, 22%–42%]; I2=58%), T2/fluid-attenuated inversion recovery-hyperintense white matter lesions 98% ([95% CI, 93%–100%]; I2=44%), lobar cerebral microbleeds 96% ([95% CI, 92%–99%]; I2=25%), gadolinium enhancing lesions 54% ([95% CI, 42%–66%]; I2=62%), cortical superficial siderosis 51% ([95% CI, 34%–68%]; I2=77%) and lobar macrohemorrhage 40% ([95% CI, 11%–73%]; I2=88%). The prevalence rate of the ApoE (Apolipoprotein E) ε4/ε4 genotype was 34% ([95% CI, 17%–53%]; I2=76%). Subgroup analyses demonstrated no differences in these prevalence rates based on study design and diagnostic strategy. Conclusions: Cognitive decline was the most common clinical feature. Hyperintense T2/fluid-attenuated inversion recovery white matter lesions and lobar cerebral microbleeds were by far the most prevalent neuroimaging findings. Thirty-four percent of patients with CAA-ri have homozygous ApoE ε4/ε4 genotype and scarce data exist regarding the cerebrospinal fluid biomarkers and its significance in these patients.

Dates et versions

hal-04642834 , version 1 (10-07-2024)

Identifiants

Citer

A. Theodorou, L. Palaiodimou, K. Malhotra, C. Zompola, A. H. Katsanos, et al.. Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.. Stroke, 2022, Stroke, 54 (1), pp.178-188. ⟨10.1161/STROKEAHA.122.040671⟩. ⟨hal-04642834⟩

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