Safety and outcome of mechanical thrombectomy in ischaemic stroke related to carotid artery dissection. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Journal of Neurology Année : 2021

Safety and outcome of mechanical thrombectomy in ischaemic stroke related to carotid artery dissection.

Résumé

Background The net clinical benefit of mechanical thrombectomy (MT) in patients with anterior circulation ischaemic stroke associated with large vessel occlusion (AIS-LVO) related to carotid artery dissection (CAD) is uncertain. The aim of the study was to investigate the safety and clinical outcomes of patients treated by MT for a CAD-related stroke. Methods We included consecutive patients with AIS-LVO treated by MT between 1st 2015 and January 1st 2020 at Lille University Hospital. We compared the safety and clinical outcomes, including successful recanalisation, defined as a modified thrombolysis in cerebral infarction (mTICI) ≥ 2b and favourable functional outcome at 3 months (defined as a modified Rankin Scale (mRS) ≤ 2 or equal to pre-stroke), in patients with CAD-related stroke versus patients with other aetiologies. Results We included 1422 patients, among them, 43 patients with CAD-related AIS-LVO were matched to 86 patients with other aetiologies. Procedural complications, sICH (ECASS-3 criteria) and mortality rates were similar in the two groups (OR 0.85, 95% CI 0.21–3.49, p = 0.82; OR 1.54 95% CI 0.33–2.79, p = 0.58; OR 0.18 95% CI 0.02–1.46, p = 0.11, respectively), as well as the rates of intracranial angiographic successful recanalisation and favourable functional outcome (OR 0.67 (95% CI 0.26–1.73, p = 0.41; OR 1.26 (95% CI 0.61–2.64, p = 0.53). In patients with CAD-related stroke, intracranial angiographic success after MT was significantly associated with favourable functional outcome. Conclusions In patients with AIS-LVO related to CAD, safety profiles and clinical outcomes after MT are similar compared to matched patients with other stroke aetiologies.
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Dates et versions

hal-04642845 , version 1 (10-07-2024)

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A. Karam, N. Bricout, M. Khyeng, Charlotte Cordonnier, Xavier Leclerc, et al.. Safety and outcome of mechanical thrombectomy in ischaemic stroke related to carotid artery dissection.. Journal of Neurology, 2021, Journal of Neurology, 269, pp.772-779. ⟨10.1007/s00415-021-10656-w⟩. ⟨hal-04642845⟩

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