Health-related quality of life profile of newly diagnosed patients with Hodgkin and non-Hodgkin lymphomas: A real-world study including 3922 patients from the French REALYSA cohort
Amélie Anota
(1)
,
Mathurine Basset
(1)
,
Emilie Charton
(1)
,
Côme Bommier
(2)
,
Fabio Efficace
(3)
,
Jehan Dupuis
(4)
,
Francesco Cottone
(3)
,
Krimo Bouabdallah
(5)
,
Caroline Mollevi
(6)
,
Loïc Ysebaert
(7, 8)
,
Audrey Winter
(9, 10, 11)
,
Fontanet Bijou
(12)
,
Marie Préau
(13, 14)
,
Adrien Chauchet
(15)
,
Adeline Bernier
(16)
,
Luc-Matthieu Fornecker
(17)
,
Hadia Hafirassou
(18)
,
Sylvain Carras
(19)
,
Florence Lachenal
(20)
,
Pauline Lionne-Huyghe
(21)
,
Laurence Detourmignies
(22)
,
Cécile Leyronnas
(23)
,
Bernard Drénou
(24)
,
Sandra Le Guyader Peyrou
(12, 25)
,
Julie Abraham
(26)
,
Alain Monnereau
(27)
,
Ludovic Fouillet
(28)
,
Franck Morschhauser
(29)
,
Cédric Rossi
(30)
,
Aurélien Belot
(31)
,
Hervé Ghesquières
(32)
1
Centre Léon Bérard [Lyon]
2 AP-HP - Hopital Saint-Louis [AP-HP]
3 GIMEMA - Italian Group for Adult Hematologic Diseases
4 Groupe Henri Mondor-Albert Chenevier
5 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
6 IDESP - Institut Desbrest de santé publique
7 CRCT - Centre de Recherches en Cancérologie de Toulouse
8 Service Hématologie - IUCT-Oncopole [CHU Toulouse]
9 Clinique Beau Soleil [Montpellier]
10 ICM - Institut régional de Cancérologie de Montpellier
11 Plateforme nationale qualité de vie et cancer
12 Institut Bergonié [Bordeaux]
13 UL2 - Université Lumière - Lyon 2
14 INSERM - Institut National de la Santé et de la Recherche Médicale
15 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
16 Community Research Laboratory Pantin - Coalition PLUS [Pantin, France]
17 ICANS - Institut de Cancérologie de Strasbourg Europe
18 LYSARC - The Lymphoma Academic Research Organisation [Lyon]
19 UGA - Université Grenoble Alpes
20 Centre Hopitalier Pierre Oudot [Bourgoin-Jallieu]
21 Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras
22 Centre Hospitalier de Roubaix
23 GHM - Groupe Hospitalier Mutualiste [Grenoble]
24 CH E.Muller Mulhouse - Centre Hospitalier Emile Muller [Mulhouse]
25 EPICENE - Cancer environnement
26 CHU Limoges
27 BPH - Bordeaux population health
28 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
29 GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365
30 CHU Dijon
31 HCL - Hospices Civils de Lyon
32 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
2 AP-HP - Hopital Saint-Louis [AP-HP]
3 GIMEMA - Italian Group for Adult Hematologic Diseases
4 Groupe Henri Mondor-Albert Chenevier
5 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
6 IDESP - Institut Desbrest de santé publique
7 CRCT - Centre de Recherches en Cancérologie de Toulouse
8 Service Hématologie - IUCT-Oncopole [CHU Toulouse]
9 Clinique Beau Soleil [Montpellier]
10 ICM - Institut régional de Cancérologie de Montpellier
11 Plateforme nationale qualité de vie et cancer
12 Institut Bergonié [Bordeaux]
13 UL2 - Université Lumière - Lyon 2
14 INSERM - Institut National de la Santé et de la Recherche Médicale
15 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
16 Community Research Laboratory Pantin - Coalition PLUS [Pantin, France]
17 ICANS - Institut de Cancérologie de Strasbourg Europe
18 LYSARC - The Lymphoma Academic Research Organisation [Lyon]
19 UGA - Université Grenoble Alpes
20 Centre Hopitalier Pierre Oudot [Bourgoin-Jallieu]
21 Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras
22 Centre Hospitalier de Roubaix
23 GHM - Groupe Hospitalier Mutualiste [Grenoble]
24 CH E.Muller Mulhouse - Centre Hospitalier Emile Muller [Mulhouse]
25 EPICENE - Cancer environnement
26 CHU Limoges
27 BPH - Bordeaux population health
28 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
29 GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365
30 CHU Dijon
31 HCL - Hospices Civils de Lyon
32 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
Caroline Mollevi
- Fonction : Auteur
- PersonId : 751492
- IdHAL : caroline-mollevi
- ORCID : 0000-0003-4827-3684
Résumé
Introduction: Considering the notable advances made in the treatment of lymphoma, assessment of health-related quality of life (HRQoL) of lymphoma patients has become a critical aspect to consider both in clinical research and routine practice. However, there is paucity of information about lymphoma specific HRQoL profile at diagnosis.
Patients and methods: HRQoL at diagnosis was assessed for 3922 adult patients with newly diagnosed high-grade (HG) (n = 1994), low-grade (LG) (n = 1053) non-Hodgkin (NHL) and Hodgkin (HL) (n = 875) lymphomas included in REal world dAta in LYmphoma and Survival in Adults (REALYSA, NCT03869619), a prospective non-interventional multicentric cohort in France. Disease-specific HRQoL aspects were assessed with three validated EORTC questionnaires, namely, the QLQ-NHL-HG29, the QLQ-NHL-LG20 and the QLQ-HL27, for patients with NHL-HG, NHL-LG and HL, respectively.
Results: We confirmed the high-level of completion of these questionnaires in REALYSA cohort, ranging from 84 % for QLQ-HG29 to 88 % for QLQ-HL27. The proportion of patients with impaired global health status was as follows: T-cell NHL, 67 %; diffuse large B-cell (DLBCL), 62 %; Burkitt, 61 %; HL, 53 %; marginal zone, 49 %; mantle cell, 48 %; follicular, 47 %. Multivariable regression analyses for DLBCL, follicular and HL showed that gender, performance status and B symptoms were independently associated with all HRQoL dimensions. However, a variable effect of age and stage were observed among these three subtypes.
Conclusions: A comprehensive analysis was made describing the HRQoL profile of newly diagnosed patients with different types of lymphomas. Our data may help to enhance the interpretation of HRQoL results in future studies using the recently validated EORTC lymphoma specific questionnaires.