Article Dans Une Revue J Inherit Metab Dis Année : 2022

Impact of the SARS-CoV-2 pandemic on the health of individuals with intoxication-type metabolic diseases - data from the E-IMD consortium.

U. Mütze
  • Fonction : Auteur
F. Gleich
  • Fonction : Auteur
I. Barić
  • Fonction : Auteur
M. Baumgartner
  • Fonction : Auteur
A. Burlina
  • Fonction : Auteur
K. A. Chapman
  • Fonction : Auteur
Y. Chien
  • Fonction : Auteur
E. Cortès-Saladelafont
  • Fonction : Auteur
C. de Laet
  • Fonction : Auteur
F. Eysken
  • Fonction : Auteur
M. Gautschi
  • Fonction : Auteur
R. Santer
  • Fonction : Auteur
J. Häberle
  • Fonction : Auteur
C. Joaquín
  • Fonction : Auteur
D. Karall
  • Fonction : Auteur
M. Lindner
  • Fonction : Auteur
A. M. Lund
  • Fonction : Auteur
C. Mühlhausen
  • Fonction : Auteur
E. Murphy
  • Fonction : Auteur
D. Roland
  • Fonction : Auteur
A. Ruiz Gomez
  • Fonction : Auteur
A. Skouma
  • Fonction : Auteur
S. C. Grünert
  • Fonction : Auteur
M. Wagenmakers
  • Fonction : Auteur
S. F. Garbade
  • Fonction : Auteur
S. Kölker
  • Fonction : Auteur
N. Boy
  • Fonction : Auteur

Résumé

The SARS-CoV-2 pandemic challenges healthcare systems worldwide. Within inherited metabolic disorders (IMDs) the vulnerable subgroup of intoxication-type IMDs such as organic acidurias (OA) and urea cycle disorders (UCD) show risk for infection-induced morbidity and mortality. This study (observation period February 2020 to December 2021) evaluates impact on medical health care as well as disease course and outcome of SARS-CoV-2 infections in patients with intoxication-type IMDs managed by participants of the European Registry and Network for intoxication type metabolic diseases Consortium (E-IMD). Survey's respondents managing 792 patients (n = 479 pediatric; n = 313 adult) with intoxication-type IMDs (n = 454 OA; n = 338 UCD) in 14 countries reported on 59 (OA: n = 36; UCD: n = 23), SARS-CoV-2 infections (7.4%). Medical services were increasingly requested (95%), mostly alleviated by remote technologies (86%). Problems with medical supply were scarce (5%). Regular follow-up visits were reduced in 41% (range 10%–50%). Most infected individuals (49/59; 83%) showed mild clinical symptoms, while 10 patients (17%; n = 6 OA including four transplanted MMA patients; n = 4 UCD) were hospitalized (metabolic decompensation in 30%). ICU treatment was not reported. Hospitalization rate did not differ for diagnosis or age group (p = 0.778). Survival rate was 100%. Full recovery was reported for 100% in outpatient care and 90% of hospitalized individuals. SARS-CoV-2 impacts health care of individuals with intoxication-type IMDs worldwide. Most infected individuals, however, showed mild symptoms and did not require hospitalization. SARS-CoV-2-induced metabolic decompensations were usually mild without increased risk for ICU treatment. Overall prognosis of infected individuals is very promising and IMD-specific or COVID-19-related complications have not been observed.
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Dates et versions

hal-04737732 , version 1 (15-10-2024)

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U. Mütze, F. Gleich, I. Barić, M. Baumgartner, A. Burlina, et al.. Impact of the SARS-CoV-2 pandemic on the health of individuals with intoxication-type metabolic diseases - data from the E-IMD consortium.. J Inherit Metab Dis, 2022, J Inherit Metab Dis, 46, pp.220-231. ⟨10.1002/jimd.12572⟩. ⟨hal-04737732⟩

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