Article Dans Une Revue Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology Année : 2023

The contribution of executive control dysfunction to freezing of gait in Parkinson's disease.

Résumé

Objective An executive dysfunction is supposed to contribute to freezing of gait (FoG) in Parkinson’s disease. We aimed to investigate at a behavioral and cortical levels whether an attentional load (particularly, a conflicting situation) can specifically impact preparation and execution phases of step initiation in parkinsonian patients with FoG. Methods Fifteen patients with FoG, 16 without and 15 controls performed an adapted version of the Attention Network Test, with step initiation as response instead of the standard manual keypress. Kinetic and kinematic features of gait initiation as well as high-resolution electroencephalography were recorded during the task. Results Patients with FoG presented an impaired executive control. Step execution time was longer in parkinsonian patients. However, the executive control effect on step execution time was not different between all groups. Compared to patients, controls showed a shorter step initiation-locked alpha desynchronization, and an earlier, more intense and shorter beta desynchronization over the sensorimotor cortex. Even though controls were faster, the induced alpha and beta activity associated with the effect of executive control didn’t differ between patients and controls. Conclusions Tasks of conflict resolution lead to a comparable alteration of step initiation and its underlying brain activity in all groups. Links between executive control, gait initiation and FoG seem more complex than expected. Significance This study questions the cognitive hypothesis in the pathophysiology of freezing of gait. Executive dysfunction is associated with FoG but is not the main causal mechanism since the interaction between attention and motor preparation didn’t provoke FoG.

Dates et versions

hal-04797606 , version 1 (22-11-2024)

Identifiants

Citer

Madli Bayot, Kathy Dujardin, Morgane Gerard, A. Braquet, Celine Tard, et al.. The contribution of executive control dysfunction to freezing of gait in Parkinson's disease.. Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 2023, Clin Neurophysiol, 152, pp.75-89. ⟨10.1016/j.clinph.2023.05.010⟩. ⟨hal-04797606⟩

Collections

INSERM UNIV-LILLE
9 Consultations
0 Téléchargements

Altmetric

Partager

More