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Gel-forming mucins structure governs mucus gels viscoelasticity.

Abstract : Mucus is the first line of innate mucosal defense in all mammals. Gelforming mucins control the rheological properties of mucus hydrogels by forming a network in which hydrophilic and hydrophobic regions coexist, and it has been revealed that the network is formed through both covalent links and reversible links such as hydrophobic interactions in order to modulate the structure as a function of the physiological necessities. Here, we review the structure and functions of the mucus in terms of the gel-forming mucins protein-protein interactions, also called interactome. Since it is difficult to characterize the low energy reversible interactions due to their dependence on physico-chemical environment, their role is not well understood. Still, they constitute a promising target to counteract mucus abnormalities observed in mucus-associated diseases.
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https://hal.univ-lille.fr/hal-02149310
Contributeur : Lilloa Université de Lille <>
Soumis le : mardi 25 juin 2019 - 15:34:38
Dernière modification le : samedi 15 mai 2021 - 03:25:10

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Bastien Demouveaux, Valérie Gouyer, Mylene Magnien, Ségolène Plet, Frederic Gottrand, et al.. Gel-forming mucins structure governs mucus gels viscoelasticity.. Medecine sciences, 2018, Medecine sciences, 34, pp.806-812. ⟨10.1051/medsci/2018206⟩. ⟨hal-02149310⟩

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