Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions

Maria-Jose Garcia Fernandez 1 Mickaël Maton Youcef Benzine 2 Nicolas Tabary 3 Elixène Jean-Baptiste Myriem Gargouri Marc Bria 4 Nicolas Blanchemain 2 Youness Karrout 2
1 CERIM - Santé publique : épidémiologie et qualité des soins-EA 2694
2 Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation
3 UMET - Unité Matériaux et Transformations - UMR 8207
4 Institut Chevreul - FR2638
Abstract : Synthetic Vascular Graft Infection (SVGI) can be very serious for patients with dramatic consequences (up to 6%). Polyester vascular grafts (PET) were modified with polymerized cyclodextrin (Poly-MeβCD) and loaded with ciprofloxacin (CFX) for the prevention of postoperative infections. The aim of this study was to investigate the CFX/Poly-MeβCD interactions and the importance of the type of the dissolution technique. The solubility of CFX was significantly improved upon Poly-MeβCD, and the interaction between CFX and Poly-MeβCD were observed by NMR (Nuclear Magnetic Resonance). Drug release was measured in phosphate buffer saline pH 7.4 at 37 °C using: (i) agitated flasks, (ii) the paddle apparatus, (iii) the conventional flow-through cells, (iv) the modified flow-through cells with agarose gel at different flow rates. Importantly, CFX release depends on the flow rate as well as the experimental set-up in vitro. CFX release from virgin prostheses (PET) was faster than from functionalized prostheses (PET-MeβCD), irrespective of the flow rate, which indicates the superiority of Poly-MeβCD in the control of CFX release. The CFX diffusion from PET-MeβCD into agarose gel showed a continuously progressive diffusion during 7 days. Thus, this test can be highly appropriate for in vitro characterization of such drug delivery systems.
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https://hal.univ-lille.fr/hal-02277932
Contributeur : Lilloa Université de Lille <>
Soumis le : mercredi 4 septembre 2019 - 08:41:37
Dernière modification le : jeudi 5 septembre 2019 - 01:25:11

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Maria-Jose Garcia Fernandez, Mickaël Maton, Youcef Benzine, Nicolas Tabary, Elixène Jean-Baptiste, et al.. Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, Journal of Drug Delivery Science and Technology, 53, pp.101166. ⟨10.1016/j.jddst.2019.101166⟩. ⟨hal-02277932⟩

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