Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions - Université de Lille Accéder directement au contenu
Article Dans Une Revue JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY Année : 2019

Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions

Résumé

Synthetic Vascular Graft Infection (SVGI) can be very serious for patients with dramatic consequences (up to 6%). Polyester vascular grafts (PET) were modified with polymerized cyclodextrin (Poly-MeβCD) and loaded with ciprofloxacin (CFX) for the prevention of postoperative infections. The aim of this study was to investigate the CFX/Poly-MeβCD interactions and the importance of the type of the dissolution technique. The solubility of CFX was significantly improved upon Poly-MeβCD, and the interaction between CFX and Poly-MeβCD were observed by NMR (Nuclear Magnetic Resonance). Drug release was measured in phosphate buffer saline pH 7.4 at 37 °C using: (i) agitated flasks, (ii) the paddle apparatus, (iii) the conventional flow-through cells, (iv) the modified flow-through cells with agarose gel at different flow rates. Importantly, CFX release depends on the flow rate as well as the experimental set-up in vitro. CFX release from virgin prostheses (PET) was faster than from functionalized prostheses (PET-MeβCD), irrespective of the flow rate, which indicates the superiority of Poly-MeβCD in the control of CFX release. The CFX diffusion from PET-MeβCD into agarose gel showed a continuously progressive diffusion during 7 days. Thus, this test can be highly appropriate for in vitro characterization of such drug delivery systems.
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hal-02277932 , version 1 (25-10-2021)

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Paternité - Pas d'utilisation commerciale

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Maria-Jose Garcia Fernandez, Mickaël Maton, Youcef Benzine, Nicolas Tabary, Elixène Jean-Baptiste, et al.. Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, Journal of Drug Delivery Science and Technology, 53, pp.101166. ⟨10.1016/j.jddst.2019.101166⟩. ⟨hal-02277932⟩
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