Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Ocular mucins in dry eye disease.

Abstract : Dry eye disease is a common and multifactorial disease with a high prevalence worldwide. Water loss, reduced expression of glycocalyx mucins, and loss of goblet cells secreting gel-forming mucins are hallmarks of dry eye disease. Mucins are large and complex heavily glycosylated proteins. Their organization in the tear film remains unclear, but they play a key role to protect and maintain integrity of the ocular surface. Mice have been extremely valuable mammalian models with which to study ocular physiology and disease, and to evaluate eye therapies. Genetically modified mice and spontaneously occurring mutants with eye defects have proven to be powerful tools for the pharmaceutical industry, clinicians, and basic researchers investigating dry eye disease. However, ocular mucins remain relatively under-studied and inadequately characterized. This review aims to summarize current knowledge about mucin production at the ocular surface in healthy individuals and in dry eye disease, and to compile an overview of mouse models available for the study of mucins in dry eye disease.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [90 références]  Voir  Masquer  Télécharger

https://hal.univ-lille.fr/hal-02281447
Contributeur : Lilloa Université de Lille <>
Soumis le : lundi 9 septembre 2019 - 11:22:52
Dernière modification le : jeudi 28 novembre 2019 - 14:12:10
Archivage à long terme le : : vendredi 7 février 2020 - 14:03:53

Fichier

 Accès restreint
Fichier visible le : 2020-12-31

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

Citation

Céline Portal, Valérie Gouyer, Frédéric Gottrand, Jean-Luc Desseyn. Ocular mucins in dry eye disease.. Experimental Eye Research, Elsevier, 2019, 186, pp.107724. ⟨10.1016/j.exer.2019.107724⟩. ⟨hal-02281447⟩

Partager

Métriques

Consultations de la notice

53