Ocular mucins in dry eye disease. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Experimental Eye Research Année : 2019

Ocular mucins in dry eye disease.

Résumé

Dry eye disease is a common and multifactorial disease with a high prevalence worldwide. Water loss, reduced expression of glycocalyx mucins, and loss of goblet cells secreting gel-forming mucins are hallmarks of dry eye disease. Mucins are large and complex heavily glycosylated proteins. Their organization in the tear film remains unclear, but they play a key role to protect and maintain integrity of the ocular surface. Mice have been extremely valuable mammalian models with which to study ocular physiology and disease, and to evaluate eye therapies. Genetically modified mice and spontaneously occurring mutants with eye defects have proven to be powerful tools for the pharmaceutical industry, clinicians, and basic researchers investigating dry eye disease. However, ocular mucins remain relatively under-studied and inadequately characterized. This review aims to summarize current knowledge about mucin production at the ocular surface in healthy individuals and in dry eye disease, and to compile an overview of mouse models available for the study of mucins in dry eye disease.

Mots clés

Domaines

Organes des sens
Fichier principal
Vignette du fichier
190625_ReviewCeline-Mucins-eye_Exp_Eye_Res_HAL.pdf (378.44 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02281447 , version 1 (09-09-2019)

Identifiants

Citer

Céline Portal, Valérie Gouyer, Frédéric Gottrand, Jean-Luc Desseyn. Ocular mucins in dry eye disease.. Experimental Eye Research, 2019, 186, pp.107724. ⟨10.1016/j.exer.2019.107724⟩. ⟨hal-02281447⟩
53 Consultations
72 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More