Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain? - Université de Lille Accéder directement au contenu
Article Dans Une Revue Schizophrenia Bulletin Année : 2016

Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain?

Matthew Hughes
  • Fonction : Auteur
Jérôme Brunelin
Flavie Waters
  • Fonction : Auteur
Ben Alderson-Day
  • Fonction : Auteur
Dave Smailes
  • Fonction : Auteur
Philipp Sterzer
  • Fonction : Auteur
Philip R. Corlett
  • Fonction : Auteur
Martin Debbané
  • Fonction : Auteur
Arnaud Cachia
Sophie Denève
  • Fonction : Auteur

Résumé

This review from the International Consortium on Hallucinations Research intends to question the pertinence of the excitatory-to-inhibitory (E/I) imbalance hypothesis as a model for hallucinations. A large number of studies suggest that subtle impairments of the E/I balance are involved in neurological and psychiatric conditions, such as schizophrenia. Emerging evidence also points to a role of the E/I balance in maintaining stable perceptual representations, suggesting it may be a plausible model for hallucinations. In support, hallucinations have been linked to inhibitory deficits as shown with impairment of gamma-aminobutyric acid transmission, N-methyl-d-aspartate receptor plasticity, reductions in gamma-frequency oscillations, hyperactivity in sensory cortices, and cognitive inhibition deficits. However, the mechanisms by which E/I dysfunctions at the cellular level might relate to clinical symptoms and cognitive deficits remain unclear. Given recent data advances in the field of clinical neuroscience, it is now possible to conduct a synthesis of available data specifically related to hallucinations. These findings are integrated with the latest computational frameworks of hallucinations, and recommendations for future research are provided.

Dates et versions

hal-02319835 , version 1 (18-10-2019)

Identifiants

Citer

Renaud Jardri, Matthew Hughes, Jérôme Brunelin, Flavie Waters, Ben Alderson-Day, et al.. Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain?. Schizophrenia Bulletin, 2016, Schizophrenia Bulletin, 42 (5), pp.1124-1134. ⟨10.1093/schbul/sbw075⟩. ⟨hal-02319835⟩
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