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Article Dans Une Revue Molecular Pharmaceutics Année : 2020

Impact of amorphisation methods on the physico-chemical properties of amorphous lactulose

Résumé

The influence of the amorphization technique on the physicochemical properties of amorphous lactulose was investigated. Four different amorphization techniques were used: quenching of the melt, milling, spray-drying, and freeze-drying, and amorphous samples were analyzed by differential scanning calorimetry, NMR spectroscopy, and powder X-ray diffraction analysis. Special attention was paid to the tautomeric composition and to the glass transition of amorphized materials. It was found that the tautomeric composition of the starting physical state (crystal, liquid, or solution) is preserved during the amorphization process and has a strong repercussion on the glass transition of the material. The correlation between these two properties as well as the plasticizing effect of the different tautomers was clarified by molecular dynamics simulations.
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Dates et versions

hal-02353960 , version 1 (25-11-2020)
hal-02353960 , version 2 (15-12-2020)
hal-02353960 , version 3 (03-03-2021)

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Citer

Frederic Ngono, Jean-François Willart, Gabriel J. Cuello, Monica Jimenez-Ruiz, Mounira Hamoudi, et al.. Impact of amorphisation methods on the physico-chemical properties of amorphous lactulose. Molecular Pharmaceutics, 2020, Molecular Pharmaceutics, 17, pp.1-9. ⟨10.1021/acs.molpharmaceut.9b00740⟩. ⟨hal-02353960v3⟩
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