Effects of Methylphenidate on Default-Mode Network/Task-Positive Network Synchronization in Children With ADHD - Université de Lille Accéder directement au contenu
Article Dans Une Revue Journal of Attention Disorders Année : 2017

Effects of Methylphenidate on Default-Mode Network/Task-Positive Network Synchronization in Children With ADHD

Laurent Querne
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  • PersonId : 1149769
  • IdRef : 069134685
Sidy Fall
Anne-Gaëlle Le Moing
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  • PersonId : 1149763
  • IdRef : 162166338
Emilie Bourel-Ponchel
Aline Delignières
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Anais Simonnot
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Alain de Broca
Catherine Gondry-Jouet
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  • PersonId : 1149985
  • IdRef : 07030467X
Patrick Berquin
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  • PersonId : 906978
  • IdRef : 076006247

Résumé

OBJECTIVE: A failure of the anti-phase synchronization between default-mode (DMN) and task-positive networks (TPN) may be involved in a main manifestation of ADHD: moment-to-moment variability. The study investigated whereby methylphenidate may improve TPN/DMN synchronization in ADHD. METHOD: Eleven drug-naive ADHD children and 11 typically developing (TD) children performed a flanker task during functional magnetic resonance imaging. The ADHD group was scanned without and 1 month later with methylphenidate. The signal was analyzed by independent component analysis. RESULTS: The TD group showed anti-phase DMN/TPN synchronization. The unmedicated ADHD group showed synchronous activity in the posterior DMN only, which was positively correlated with response time variability for the flanker task. Methylphenidate initiated a partial anti-phase TPN/DMN synchronization, reduced variability, and abolished the variability/DMN correlation. CONCLUSION: Although results should be interpreted cautiously because the sample size is small, they suggest that a failure of the TPN/DMN synchronization could be involved in the moment-to-moment variability in ADHD. Methylphenidate initiated TPN/DMN synchronization, which in turn appeared to reduce variability.
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Dates et versions

hal-02355523 , version 1 (08-11-2019)

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Citer

Laurent Querne, Sidy Fall, Anne-Gaëlle Le Moing, Emilie Bourel-Ponchel, Aline Delignières, et al.. Effects of Methylphenidate on Default-Mode Network/Task-Positive Network Synchronization in Children With ADHD. Journal of Attention Disorders, 2017, Journal of Attention Disorders, 21 (14), pp.1208-1220. ⟨10.1177/1087054713517542⟩. ⟨hal-02355523⟩
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