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Effects of Methylphenidate on Default-Mode Network/Task-Positive Network Synchronization in Children With ADHD
Abstract : OBJECTIVE: A failure of the anti-phase synchronization between default-mode (DMN) and task-positive networks (TPN) may be involved in a main manifestation of ADHD: moment-to-moment variability. The study investigated whereby methylphenidate may improve TPN/DMN synchronization in ADHD. METHOD: Eleven drug-naive ADHD children and 11 typically developing (TD) children performed a flanker task during functional magnetic resonance imaging. The ADHD group was scanned without and 1 month later with methylphenidate. The signal was analyzed by independent component analysis. RESULTS: The TD group showed anti-phase DMN/TPN synchronization. The unmedicated ADHD group showed synchronous activity in the posterior DMN only, which was positively correlated with response time variability for the flanker task. Methylphenidate initiated a partial anti-phase TPN/DMN synchronization, reduced variability, and abolished the variability/DMN correlation. CONCLUSION: Although results should be interpreted cautiously because the sample size is small, they suggest that a failure of the TPN/DMN synchronization could be involved in the moment-to-moment variability in ADHD. Methylphenidate initiated TPN/DMN synchronization, which in turn appeared to reduce variability.
https://hal.univ-lille.fr/hal-02355523
Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 8 novembre 2019 - 11:57:37
Dernière modification le : mardi 3 novembre 2020 - 10:26:01
Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 8 novembre 2019 - 11:57:37
Dernière modification le : mardi 3 novembre 2020 - 10:26:01