Mesh:Contrast Media* Mesh:Image Enhancement Mesh:Brain/pathology Mesh:Gadolinium* Mesh:Multiple Sclerosis/pathology Mesh:Multiple Sclerosis/diagnostic imaging* Mesh:Male Mesh:Adult Mesh:Brain/diagnostic imaging* Mesh:Observer Variation Mesh:Humans Mesh:Young Adult Mesh:Magnetic Resonance Imaging/methods* Mesh:Image Processing Mesh:Computer-Assisted/methods* Mesh:Female Multiple sclerosis Double inversion recovery MR sequence Gadolinium-based contrast agent Clinically isolated syndrome Active enhancing inflammatory lesions