The dose–effect relationship of baclofen in alcohol dependence: A 1-year cohort study

Abstract : Objective Our aim is to study the relationship between dose of baclofen and effectiveness in alcohol dependence. Methods Two hundred two patients with alcohol dependence, who received baclofen treatment for drinking reduction, were followed up for 1 year. For each patient-month of treatment, the maximum daily dose of baclofen (DDB) and average weekly alcohol consumption (AWAC) were calculated. We defined a favorable drinking outcome as an AWAC under 200 g/w for at least 2 consecutive months. We divided the DDB of each patient-month into 3 categories (low dose: <90 mg/d, medium dose: 90–150 mg/d, and high dose: >150 mg/d) and investigated the relationship between reaching a favorable outcome and the concurrent DDB category in a time-varying Cox regression analysis. Hazard ratios (HRs) were adjusted based on age, sex, and initial AWAC. Results One hundred forty subjects were followed during at least 1 month. Of these patients, 58 (41%) had a favorable drinking outcome. In comparison to low dose, medium dose was associated with a decreased rate of favorable drinking outcome (HR = 0.42; 95% CI [0.20, 0.88]), whereas no difference was found with high dose (HR = 1.31; 95% CI [0.65, 2.64]). Conclusion The relationship between dose of baclofen and favorable drinking outcome was U-shaped, that is, was increased at low and high doses compared to medium doses.
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https://hal.univ-lille.fr/hal-02369071
Contributeur : Lilloa Université de Lille <>
Soumis le : lundi 18 novembre 2019 - 17:33:52
Dernière modification le : mardi 19 novembre 2019 - 01:37:02

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Baptiste Pignon, Julien Labreuche, Marine Auffret, Sophie Gautier, Sylvie Deheul, et al.. The dose–effect relationship of baclofen in alcohol dependence: A 1-year cohort study. Human Psychopharmacology. Clinical and Experimental, 2017, Human Psychopharmacology. Clinical and Experimental, 32 (4), ⟨10.1002/hup.2593⟩. ⟨hal-02369071⟩

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