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Dose-dependent metabolite changes after ethanol intoxication in rat prefrontal cortex using in vivo magnetic resonance spectroscopy

Louise Carton 1, 2, 3 Florent Auger 1 Maéva Kyheng 3, 4 Maud Petrault 1, 3 Nicolas Durieux Delphine Allorge 5 Olivier Cottencin 6, 3 Renaud Jardri 6, 2 Regis Bordet 1, 3 Benjamin Rolland 7, 8
1 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171
2 Service de Psychiatrie [CHRU Lille]
3 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
4 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
5 IMPECS - Impact de l'environnement chimique sur la santé humaine
6 SCALab - Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
7 Centre Hospitalier le Vinatier [Bron]
8 CRNL - Centre de recherche en neurosciences de Lyon
Abstract : Ethanol disrupts the balance between the excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmission systems. We aimed to assess how acute ethanol intoxication in rats affects the levels of GABA, glutamate and other cerebral metabolites after injection of two different doses of ethanol. One in vivo magnetic resonance spectrum of the prefrontal cortex region was acquired before and six spectra were acquired after intraperitoneal injections of saline or ethanol (1 g/kg or 2 g/kg). Brain kinetics after exposure to ethanol were compared to blood ethanol kinetics. GABA levels significantly decreased after injection of 1 g/kg but not 2 g/kg doses of ethanol. Choline levels, which serve as a marker of alterations in membrane composition, significantly decreased after injection of 2 g/kg but not 1 g/kg doses of ethanol. Acute ethanol intoxication appears to result in specific dose-dependent changes in the GABA level and choline level.
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https://hal.univ-lille.fr/hal-02447542
Contributeur : Lilloa Université de Lille <>
Soumis le : mardi 21 janvier 2020 - 16:35:16
Dernière modification le : mardi 3 novembre 2020 - 15:54:06

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UNIV-LILLE | SCALAB | CNRS | UNIV-ST-ETIENNE | UNIV-LYON1 | UDL

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Louise Carton, Florent Auger, Maéva Kyheng, Maud Petrault, Nicolas Durieux, et al.. Dose-dependent metabolite changes after ethanol intoxication in rat prefrontal cortex using in vivo magnetic resonance spectroscopy. Scientific Reports, Nature Publishing Group, 2019, Scientific Reports, 9, pp.10682. ⟨10.1038/s41598-019-47187-4⟩. ⟨hal-02447542⟩

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