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The impact of discontinuing methylphenidate on weight and eating behavior
Abstract : Chronic administration of the amphetamine-derivative methylphenidate (MPH) may induce appetite reduction and weight loss. By contrast, the effects that stopping chronic MPH may exert on eating behavior and body weight are poorly known. We report the case of a male patient with childhood attention deficit/hyperactivity disorder (ADHD), who discontinued MPH treatment at the age of 11 years and was lost to follow-up until the age of 16. The patient's body mass index increased by five points within 1 year of MPH cessation while the symptoms of ADHD were re-emerging. The patient secondarily developed DSM-5 criteria for eating disorders. Discontinuing chronic MPH can significantly affect weight and eating behavior. Such risks should warrant further studies, as they could be particularly increased in patients with ADHD, who share common vulnerability factors with both obesity and eating disorders.
Keywords :
Adolescent
Central Nervous System Stimulants/therapeutic use*
Attention Deficit Disorder with Hyperactivity/drug therapy*
Body Mass Index
Feeding Behavior/drug effects*
Weight Gain/drug effects*
Recurrence
Methylphenidate/therapeutic use*
Male
Humans
attention deficit disorder with hyperactivity
eating disorders
methylphenidate
pharmacovigilance
amphetamines
weight gain
drug toxicity
https://hal.univ-lille.fr/hal-02467021
Contributeur : LillOA Université de Lille Connectez-vous pour contacter le contributeur
Soumis le : mardi 4 février 2020 - 17:39:48
Dernière modification le : vendredi 10 avril 2020 - 01:43:21
Contributeur : LillOA Université de Lille Connectez-vous pour contacter le contributeur
Soumis le : mardi 4 février 2020 - 17:39:48
Dernière modification le : vendredi 10 avril 2020 - 01:43:21
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