The impact of discontinuing methylphenidate on weight and eating behavior

Victoire Benard 1 Olivier Cottencin 1 Dewi Guardia 2 Guillaume Vaiva 1 Benjamin Rolland
1 SCALab - Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
2 JPArc - U837 Inserm - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer
Abstract : Chronic administration of the amphetamine-derivative methylphenidate (MPH) may induce appetite reduction and weight loss. By contrast, the effects that stopping chronic MPH may exert on eating behavior and body weight are poorly known. We report the case of a male patient with childhood attention deficit/hyperactivity disorder (ADHD), who discontinued MPH treatment at the age of 11 years and was lost to follow-up until the age of 16. The patient's body mass index increased by five points within 1 year of MPH cessation while the symptoms of ADHD were re-emerging. The patient secondarily developed DSM-5 criteria for eating disorders. Discontinuing chronic MPH can significantly affect weight and eating behavior. Such risks should warrant further studies, as they could be particularly increased in patients with ADHD, who share common vulnerability factors with both obesity and eating disorders.
Keywords : drug toxicity weight gain amphetamines pharmacovigilance eating disorders methylphenidate attention deficit disorder with hyperactivity Mesh:Humans Mesh:Central Nervous System Stimulants/therapeutic use* Mesh:Adolescent Mesh:Attention Deficit Disorder with Hyperactivity/drug therapy* Mesh:Body Mass Index Mesh:Feeding Behavior/drug effects* Mesh:Weight Gain/drug effects* Mesh:Recurrence Mesh:Methylphenidate/therapeutic use* Mesh:Male
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https://hal.univ-lille.fr/hal-02467021
Contributeur : Lilloa Université de Lille <>
Soumis le : mardi 4 février 2020 - 17:39:48
Dernière modification le : mercredi 5 février 2020 - 01:30:47

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Victoire Benard, Olivier Cottencin, Dewi Guardia, Guillaume Vaiva, Benjamin Rolland. The impact of discontinuing methylphenidate on weight and eating behavior. International Journal of Eating Disorders, Wiley, 2014, The International Journal of Eating Disorders, 48 (3), pp.345-348. ⟨10.1002/eat.22301⟩. ⟨hal-02467021⟩

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