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The impact of discontinuing methylphenidate on weight and eating behavior
Abstract : Chronic administration of the amphetamine-derivative methylphenidate (MPH) may induce appetite reduction and weight loss. By contrast, the effects that stopping chronic MPH may exert on eating behavior and body weight are poorly known. We report the case of a male patient with childhood attention deficit/hyperactivity disorder (ADHD), who discontinued MPH treatment at the age of 11 years and was lost to follow-up until the age of 16. The patient's body mass index increased by five points within 1 year of MPH cessation while the symptoms of ADHD were re-emerging. The patient secondarily developed DSM-5 criteria for eating disorders. Discontinuing chronic MPH can significantly affect weight and eating behavior. Such risks should warrant further studies, as they could be particularly increased in patients with ADHD, who share common vulnerability factors with both obesity and eating disorders.
Keywords :
Mesh:Recurrence
Mesh:Weight Gain/drug effects*
drug toxicity
weight gain
amphetamines
pharmacovigilance
eating disorders
methylphenidate
attention deficit disorder with hyperactivity
Mesh:Humans
Mesh:Central Nervous System Stimulants/therapeutic use*
Mesh:Adolescent
Mesh:Attention Deficit Disorder with Hyperactivity/drug therapy*
Mesh:Body Mass Index
Mesh:Feeding Behavior/drug effects*
Mesh:Methylphenidate/therapeutic use*
Mesh:Male
https://hal.univ-lille.fr/hal-02467021
Contributeur : Lilloa Université de Lille <>
Soumis le : mardi 4 février 2020 - 17:39:48
Dernière modification le : mardi 17 mars 2020 - 14:02:17
Contributeur : Lilloa Université de Lille <>
Soumis le : mardi 4 février 2020 - 17:39:48
Dernière modification le : mardi 17 mars 2020 - 14:02:17
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